Dynamic divisive normalization predicts time-varying value coding in decision-related circuits

Kenway Louie, Thomas Lofaro, Ryan Webb, Paul Glimcher

Research output: Contribution to journalArticle

Abstract

Normalization is a widespread neural computation, mediating divisive gain control in sensory processing and implementing a context-dependent value code in decision-related frontal and parietal cortices. Although decision-making is a dynamic process with complex temporal characteristics, most models of normalization are time-independent and little is known about the dynamic interaction of normalization and choice. Here, we show that a simple differential equation model of normalization explains the characteristic phasic-sustained pattern of cortical decision activity and predicts specific normalization dynamics: value coding during initial transients, time-varying value modulation, and delayed onset of contextual information. Empirically, we observe these predicted dynamics in saccade-related neurons in monkey lateral intraparietal cortex. Furthermore, such models naturally incorporate a time-weighted average of past activity, implementing an intrinsic reference-dependence in value coding. These results suggest that a single network mechanism can explain both transient and sustained decision activity, emphasizing the importance of a dynamic view of normalization in neural coding.

Original languageEnglish (US)
Pages (from-to)16046-16057
Number of pages12
JournalJournal of Neuroscience
Volume34
Issue number48
DOIs
StatePublished - Nov 26 2014

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Parietal Lobe
Saccades
Frontal Lobe
Haplorhini
Decision Making
Neurons

Keywords

  • Computational modeling
  • Decision-making
  • Divisive normalization
  • Dynamical system
  • Reward

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dynamic divisive normalization predicts time-varying value coding in decision-related circuits. / Louie, Kenway; Lofaro, Thomas; Webb, Ryan; Glimcher, Paul.

In: Journal of Neuroscience, Vol. 34, No. 48, 26.11.2014, p. 16046-16057.

Research output: Contribution to journalArticle

Louie, Kenway ; Lofaro, Thomas ; Webb, Ryan ; Glimcher, Paul. / Dynamic divisive normalization predicts time-varying value coding in decision-related circuits. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 48. pp. 16046-16057.
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