Dyeing polymorphs

The MALDI host 2,5-dihydroxybenzoic acid

Dawn E. Cohen, Jason B. Benedict, Brian Morlan, Daniel T. Chiu, Bart Kahr

Research output: Contribution to journalArticle

Abstract

The dye methyl red was used to distinguish concomitant polymorphs of the matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) host, 2,5-dihydroxybenzoic acid. Red and purple crystals were readily separated by inspection. They corresponded to the known Form I (P21/c, a = 4.9110(3) Å, b = 11.8280(7) Å, c = 11.0580(6) Å, β = 91.059(3)°, V = 642.22 Å3) and Form II (P21/c, a = 5.5610(2) Å, b = 4.8690(1) Å, c = 23.6880 (8) Å, β = 100.191(1)°, V = 631.27 Å3), respectively. X-ray structures of cocrystals of dihydroxybenzoic acids and methyl red, measurements of the linear dichroism of mixed crystals, and force-field calculations were used to investigate the mechanism of differential coloring. The relevance of the observations to investigations of the MALDI mechanism are discussed.

Original languageEnglish (US)
Pages (from-to)492-495
Number of pages4
JournalCrystal Growth and Design
Volume7
Issue number3
DOIs
StatePublished - Mar 2007

Fingerprint

Polymorphism
lissamine rhodamine B
Dyeing
Crystals
acids
Acids
Dichroism
mixed crystals
Coloring
field theory (physics)
dichroism
crystal field theory
Ionization
Mass spectrometry
inspection
Desorption
Coloring Agents
mass spectroscopy
Dyes
Inspection

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Dyeing polymorphs : The MALDI host 2,5-dihydroxybenzoic acid. / Cohen, Dawn E.; Benedict, Jason B.; Morlan, Brian; Chiu, Daniel T.; Kahr, Bart.

In: Crystal Growth and Design, Vol. 7, No. 3, 03.2007, p. 492-495.

Research output: Contribution to journalArticle

Cohen, DE, Benedict, JB, Morlan, B, Chiu, DT & Kahr, B 2007, 'Dyeing polymorphs: The MALDI host 2,5-dihydroxybenzoic acid', Crystal Growth and Design, vol. 7, no. 3, pp. 492-495. https://doi.org/10.1021/cg060887w
Cohen, Dawn E. ; Benedict, Jason B. ; Morlan, Brian ; Chiu, Daniel T. ; Kahr, Bart. / Dyeing polymorphs : The MALDI host 2,5-dihydroxybenzoic acid. In: Crystal Growth and Design. 2007 ; Vol. 7, No. 3. pp. 492-495.
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