Dyeing crystals to dyeing tissues

Congo red in anisotropic media

Miki Kurimoto, Beat Müller, Werner Kaminsky, Bart Kahr, Lee Way Jin

Research output: Contribution to journalArticle

Abstract

In the past, we have studied the process of dyeing crystals through measurements of linear optical anisotropies (e.g., linear dichroism and linear birefringence). Techniques for analyzing the optical properties of dyed crystals are readily translated to stained crystalline tissues, countless examples of which have been described by chemical histologists. Moreover, questions pertaining to mechanisms of non-covalent association are comparable whether the structured host is a single crystal or crystalline tissue. Here, the azo dye, Congo red, in two types of anisotropic media, sucrose single crystals and fibrous, proteinaceous amyloid plaques, is described. Optical micrographs of amyloid from the brains of deceased Alzheimer's Disease patients made with a newly developed imaging system reveal previously unrecognized features. As formation of ordered amyloid plaques from their relatively small peptides may well be considered a pathological biocrystallization process, a clear understanding of the deposition mechanism may lead to strategies for crystallization inhibition.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalMolecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals
Volume389
Issue numberPART I
DOIs
StatePublished - 2002

Fingerprint

Congo Red
Anisotropic media
anisotropic media
Amyloid
Dyeing
Tissue
Crystals
sucrose
single crystals
Azo Compounds
Single crystals
dichroism
Crystalline materials
crystals
peptides
brain
birefringence
Optical anisotropy
Azo dyes
dyes

Keywords

  • Alzheimer's Disease
  • Amyloid
  • Birefringence imaging
  • Congo red
  • Dyeing crystals

ASJC Scopus subject areas

  • Condensed Matter Physics

Cite this

Dyeing crystals to dyeing tissues : Congo red in anisotropic media. / Kurimoto, Miki; Müller, Beat; Kaminsky, Werner; Kahr, Bart; Jin, Lee Way.

In: Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, Vol. 389, No. PART I, 2002, p. 1-9.

Research output: Contribution to journalArticle

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