Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia

Miranda H. Chakos, Scott A. Schobel, Hongbin Gu, Guido Gerig, Daniel Bradford, Cecil Charles, Jeffrey A. Lieberman

    Research output: Contribution to journalArticle

    Abstract

    Background: Reduced hippocampal volume is a consistently described structural abnormality in schizophrenia but its cause and timing are not known. Aims: To examine the relationship of duration of schizophrenic illness and treatment effects with hippocampal volumes. Method: Quantitative 1.5 T magnetic resonance imaging brain scans of young male patients in the early stage of schizophrenic illness were compared with those of chronically ill older patients. Scans were also acquired for controls matched to both patient groups for age and handedness. Duration of illness was recorded and severity of symptoms assessed with the Positive and Negative Syndrome Scale. Results: The patients with schizophrenia had smaller hippocampal volumes than the controls. The volume reduction was larger in older patients than in young, compared with age-matched controls. In the early illness group atypical antipsychotics rather than haloperidol were associated with larger hippocampal volumes even after controlling for differences in illness severity. Conclusions: The greater reduction of hippocampal volume in people with chronic v. early illness, after controlling for illness severity and age, supports the hypothesis of progressive hippocampal reduction in males with schizophrenia. Atypical antipsychotics early in illness may protect against this.

    Original languageEnglish (US)
    Pages (from-to)26-31
    Number of pages6
    JournalBritish Journal of Psychiatry
    Volume186
    Issue numberJAN.
    DOIs
    StatePublished - Jan 2005

    Fingerprint

    Schizophrenia
    Antipsychotic Agents
    Therapeutics
    Functional Laterality
    Haloperidol
    Chronic Disease
    Age Groups
    Magnetic Resonance Imaging
    Brain

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Psychiatry and Mental health

    Cite this

    Chakos, M. H., Schobel, S. A., Gu, H., Gerig, G., Bradford, D., Charles, C., & Lieberman, J. A. (2005). Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia. British Journal of Psychiatry, 186(JAN.), 26-31. https://doi.org/10.1192/bjp.186.1.26

    Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia. / Chakos, Miranda H.; Schobel, Scott A.; Gu, Hongbin; Gerig, Guido; Bradford, Daniel; Charles, Cecil; Lieberman, Jeffrey A.

    In: British Journal of Psychiatry, Vol. 186, No. JAN., 01.2005, p. 26-31.

    Research output: Contribution to journalArticle

    Chakos, MH, Schobel, SA, Gu, H, Gerig, G, Bradford, D, Charles, C & Lieberman, JA 2005, 'Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia', British Journal of Psychiatry, vol. 186, no. JAN., pp. 26-31. https://doi.org/10.1192/bjp.186.1.26
    Chakos, Miranda H. ; Schobel, Scott A. ; Gu, Hongbin ; Gerig, Guido ; Bradford, Daniel ; Charles, Cecil ; Lieberman, Jeffrey A. / Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia. In: British Journal of Psychiatry. 2005 ; Vol. 186, No. JAN. pp. 26-31.
    @article{f265bae8d29e47c89ce4e525b251ae0a,
    title = "Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia",
    abstract = "Background: Reduced hippocampal volume is a consistently described structural abnormality in schizophrenia but its cause and timing are not known. Aims: To examine the relationship of duration of schizophrenic illness and treatment effects with hippocampal volumes. Method: Quantitative 1.5 T magnetic resonance imaging brain scans of young male patients in the early stage of schizophrenic illness were compared with those of chronically ill older patients. Scans were also acquired for controls matched to both patient groups for age and handedness. Duration of illness was recorded and severity of symptoms assessed with the Positive and Negative Syndrome Scale. Results: The patients with schizophrenia had smaller hippocampal volumes than the controls. The volume reduction was larger in older patients than in young, compared with age-matched controls. In the early illness group atypical antipsychotics rather than haloperidol were associated with larger hippocampal volumes even after controlling for differences in illness severity. Conclusions: The greater reduction of hippocampal volume in people with chronic v. early illness, after controlling for illness severity and age, supports the hypothesis of progressive hippocampal reduction in males with schizophrenia. Atypical antipsychotics early in illness may protect against this.",
    author = "Chakos, {Miranda H.} and Schobel, {Scott A.} and Hongbin Gu and Guido Gerig and Daniel Bradford and Cecil Charles and Lieberman, {Jeffrey A.}",
    year = "2005",
    month = "1",
    doi = "10.1192/bjp.186.1.26",
    language = "English (US)",
    volume = "186",
    pages = "26--31",
    journal = "British Journal of Psychiatry",
    issn = "0007-1250",
    publisher = "Royal College of Psychiatrists",
    number = "JAN.",

    }

    TY - JOUR

    T1 - Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia

    AU - Chakos, Miranda H.

    AU - Schobel, Scott A.

    AU - Gu, Hongbin

    AU - Gerig, Guido

    AU - Bradford, Daniel

    AU - Charles, Cecil

    AU - Lieberman, Jeffrey A.

    PY - 2005/1

    Y1 - 2005/1

    N2 - Background: Reduced hippocampal volume is a consistently described structural abnormality in schizophrenia but its cause and timing are not known. Aims: To examine the relationship of duration of schizophrenic illness and treatment effects with hippocampal volumes. Method: Quantitative 1.5 T magnetic resonance imaging brain scans of young male patients in the early stage of schizophrenic illness were compared with those of chronically ill older patients. Scans were also acquired for controls matched to both patient groups for age and handedness. Duration of illness was recorded and severity of symptoms assessed with the Positive and Negative Syndrome Scale. Results: The patients with schizophrenia had smaller hippocampal volumes than the controls. The volume reduction was larger in older patients than in young, compared with age-matched controls. In the early illness group atypical antipsychotics rather than haloperidol were associated with larger hippocampal volumes even after controlling for differences in illness severity. Conclusions: The greater reduction of hippocampal volume in people with chronic v. early illness, after controlling for illness severity and age, supports the hypothesis of progressive hippocampal reduction in males with schizophrenia. Atypical antipsychotics early in illness may protect against this.

    AB - Background: Reduced hippocampal volume is a consistently described structural abnormality in schizophrenia but its cause and timing are not known. Aims: To examine the relationship of duration of schizophrenic illness and treatment effects with hippocampal volumes. Method: Quantitative 1.5 T magnetic resonance imaging brain scans of young male patients in the early stage of schizophrenic illness were compared with those of chronically ill older patients. Scans were also acquired for controls matched to both patient groups for age and handedness. Duration of illness was recorded and severity of symptoms assessed with the Positive and Negative Syndrome Scale. Results: The patients with schizophrenia had smaller hippocampal volumes than the controls. The volume reduction was larger in older patients than in young, compared with age-matched controls. In the early illness group atypical antipsychotics rather than haloperidol were associated with larger hippocampal volumes even after controlling for differences in illness severity. Conclusions: The greater reduction of hippocampal volume in people with chronic v. early illness, after controlling for illness severity and age, supports the hypothesis of progressive hippocampal reduction in males with schizophrenia. Atypical antipsychotics early in illness may protect against this.

    UR - http://www.scopus.com/inward/record.url?scp=11244255430&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=11244255430&partnerID=8YFLogxK

    U2 - 10.1192/bjp.186.1.26

    DO - 10.1192/bjp.186.1.26

    M3 - Article

    VL - 186

    SP - 26

    EP - 31

    JO - British Journal of Psychiatry

    JF - British Journal of Psychiatry

    SN - 0007-1250

    IS - JAN.

    ER -