Duplication, divergence and formation of novel protein topologies

Christine Vogel, Veronica Morea

Research output: Contribution to journalArticle

Abstract

The rearrangement or permutation of protein substructures is an important mode of divergence. Recent work explored one possible underlying mechanism called permutation-by-duplication, which produces special forms of motif rearrangements called circular permutations. Permutation-by-duplication, involving gene duplication, fusion and truncation, can produce fully functional intermediate proteins and thus represents a feasible mechanism of protein evolution. In spite of this, circular permutations are relatively rare and we discuss possible reasons for their existence.

Original languageEnglish (US)
Pages (from-to)973-978
Number of pages6
JournalBioEssays
Volume28
Issue number10
DOIs
StatePublished - Oct 2006

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topology
Topology
Proteins
Gene Duplication
proteins
Gene Fusion
gene duplication
Fusion reactions
Genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology
  • Developmental Biology
  • Neuroscience (miscellaneous)

Cite this

Duplication, divergence and formation of novel protein topologies. / Vogel, Christine; Morea, Veronica.

In: BioEssays, Vol. 28, No. 10, 10.2006, p. 973-978.

Research output: Contribution to journalArticle

Vogel, Christine ; Morea, Veronica. / Duplication, divergence and formation of novel protein topologies. In: BioEssays. 2006 ; Vol. 28, No. 10. pp. 973-978.
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