Dot by dot: Analyzing the glycome using lectin microarrays

João P. Ribeiro, Lara K. Mahal

Research output: Contribution to journalReview article

Abstract

The glycome, that is, the cohort of carbohydrates within a cell or tissue, plays a key part in diverse biological interactions involved in health and disease. Glycans are structurally complex and notoriously difficult to analyze. Lectin microarrays, a sensitive and high-throughput method for glycomic profiling, provide a global view of the glycome. In recent work, this technology has been successfully applied to a wide range of studies, from identification of glycan-based stem cell markers to the detection of pathogens and early diagnosis of disease. This review focuses on advances in the field of lectin microarrays.

Original languageEnglish (US)
Pages (from-to)827-831
Number of pages5
JournalCurrent Opinion in Chemical Biology
Volume17
Issue number5
DOIs
StatePublished - Oct 1 2013

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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