Do metropolitan HIV epidemic histories and programs for people who inject drugs and men who have sex with men predict AIDS incidence and mortality among heterosexuals?

Samuel R. Friedman, Brooke S. West, Barbara Tempalski, Cory M. Morton, Charles M. Cleland, Don Des Jarlais, H. Irene Hall, Hannah L.F. Cooper

Research output: Contribution to journalArticle

Abstract

Purpose: We focus on a little-researched issue-how human immunodeficiency virus (HIV) epidemics and programs in key populations in metropolitan areas affect epidemics in other key populations. We consider (1) How are earlier epidemics among people who inject drugs (PWID) and men who have sex with men (MSM) related to later AIDS incidence and mortality among heterosexuals?; (2) Were prevention programs targeting PWID or MSM associated with lower AIDS incidence and mortality among heterosexuals?; and (3) Was the size of the potential bridge population of noninjecting drug users (NIDUs) in a metropolitan area associated with later AIDS incidence and mortality among heterosexuals? Methods: Using data for 96 large U.S. metropolitan areas, Poisson regression assessed associations of population prevalences of HIV-infected PWID and MSM (1992); NIDU population prevalence (1992-1994); drug use treatment coverage for PWID (1993); HIV counseling and testing coverage for MSM and for PWID (1992); and syringe exchange presence (2000) with CDC data on AIDS incidence and mortality among heterosexuals in 2006-2008, with appropriate socioeconomic controls. Results: Population density of HIV+ PWID and of NIDUs were positively related, and prevention programs for PWID negatively related to later AIDS incidence among heterosexuals and later mortality among heterosexuals living with AIDS. HIV+ MSM population density and prevention programs for MSM were not associated with these outcomes. Conclusions: Efforts to reduce HIV transmission among PWID and NIDUs may reduce AIDS and AIDS-related mortality among heterosexuals. More research is needed at metropolitan area, network, and individual levels into HIV bridging across key populations and how interventions in one key population affect HIV epidemics in other key populations.

Original languageEnglish (US)
Pages (from-to)304-311
Number of pages8
JournalAnnals of Epidemiology
Volume24
Issue number4
DOIs
StatePublished - Jan 1 2014

Fingerprint

Heterosexuality
Acquired Immunodeficiency Syndrome
HIV
Mortality
Incidence
Pharmaceutical Preparations
Drug Users
Population
Population Density
Syringes
Centers for Disease Control and Prevention (U.S.)
Counseling

Keywords

  • Bridging
  • Epidemics
  • Heterosexuals
  • HIV/AIDS
  • IDU
  • Men who have sex with men
  • Metropolitan areas
  • MSM
  • People who inject drugs
  • Urban health

ASJC Scopus subject areas

  • Epidemiology

Cite this

Do metropolitan HIV epidemic histories and programs for people who inject drugs and men who have sex with men predict AIDS incidence and mortality among heterosexuals? / Friedman, Samuel R.; West, Brooke S.; Tempalski, Barbara; Morton, Cory M.; Cleland, Charles M.; Des Jarlais, Don; Hall, H. Irene; Cooper, Hannah L.F.

In: Annals of Epidemiology, Vol. 24, No. 4, 01.01.2014, p. 304-311.

Research output: Contribution to journalArticle

Friedman, Samuel R. ; West, Brooke S. ; Tempalski, Barbara ; Morton, Cory M. ; Cleland, Charles M. ; Des Jarlais, Don ; Hall, H. Irene ; Cooper, Hannah L.F. / Do metropolitan HIV epidemic histories and programs for people who inject drugs and men who have sex with men predict AIDS incidence and mortality among heterosexuals?. In: Annals of Epidemiology. 2014 ; Vol. 24, No. 4. pp. 304-311.
@article{3075b627ba2245c188943d299a8d09f7,
title = "Do metropolitan HIV epidemic histories and programs for people who inject drugs and men who have sex with men predict AIDS incidence and mortality among heterosexuals?",
abstract = "Purpose: We focus on a little-researched issue-how human immunodeficiency virus (HIV) epidemics and programs in key populations in metropolitan areas affect epidemics in other key populations. We consider (1) How are earlier epidemics among people who inject drugs (PWID) and men who have sex with men (MSM) related to later AIDS incidence and mortality among heterosexuals?; (2) Were prevention programs targeting PWID or MSM associated with lower AIDS incidence and mortality among heterosexuals?; and (3) Was the size of the potential bridge population of noninjecting drug users (NIDUs) in a metropolitan area associated with later AIDS incidence and mortality among heterosexuals? Methods: Using data for 96 large U.S. metropolitan areas, Poisson regression assessed associations of population prevalences of HIV-infected PWID and MSM (1992); NIDU population prevalence (1992-1994); drug use treatment coverage for PWID (1993); HIV counseling and testing coverage for MSM and for PWID (1992); and syringe exchange presence (2000) with CDC data on AIDS incidence and mortality among heterosexuals in 2006-2008, with appropriate socioeconomic controls. Results: Population density of HIV+ PWID and of NIDUs were positively related, and prevention programs for PWID negatively related to later AIDS incidence among heterosexuals and later mortality among heterosexuals living with AIDS. HIV+ MSM population density and prevention programs for MSM were not associated with these outcomes. Conclusions: Efforts to reduce HIV transmission among PWID and NIDUs may reduce AIDS and AIDS-related mortality among heterosexuals. More research is needed at metropolitan area, network, and individual levels into HIV bridging across key populations and how interventions in one key population affect HIV epidemics in other key populations.",
keywords = "Bridging, Epidemics, Heterosexuals, HIV/AIDS, IDU, Men who have sex with men, Metropolitan areas, MSM, People who inject drugs, Urban health",
author = "Friedman, {Samuel R.} and West, {Brooke S.} and Barbara Tempalski and Morton, {Cory M.} and Cleland, {Charles M.} and {Des Jarlais}, Don and Hall, {H. Irene} and Cooper, {Hannah L.F.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.annepidem.2014.01.008",
language = "English (US)",
volume = "24",
pages = "304--311",
journal = "Annals of Epidemiology",
issn = "1047-2797",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Do metropolitan HIV epidemic histories and programs for people who inject drugs and men who have sex with men predict AIDS incidence and mortality among heterosexuals?

AU - Friedman, Samuel R.

AU - West, Brooke S.

AU - Tempalski, Barbara

AU - Morton, Cory M.

AU - Cleland, Charles M.

AU - Des Jarlais, Don

AU - Hall, H. Irene

AU - Cooper, Hannah L.F.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: We focus on a little-researched issue-how human immunodeficiency virus (HIV) epidemics and programs in key populations in metropolitan areas affect epidemics in other key populations. We consider (1) How are earlier epidemics among people who inject drugs (PWID) and men who have sex with men (MSM) related to later AIDS incidence and mortality among heterosexuals?; (2) Were prevention programs targeting PWID or MSM associated with lower AIDS incidence and mortality among heterosexuals?; and (3) Was the size of the potential bridge population of noninjecting drug users (NIDUs) in a metropolitan area associated with later AIDS incidence and mortality among heterosexuals? Methods: Using data for 96 large U.S. metropolitan areas, Poisson regression assessed associations of population prevalences of HIV-infected PWID and MSM (1992); NIDU population prevalence (1992-1994); drug use treatment coverage for PWID (1993); HIV counseling and testing coverage for MSM and for PWID (1992); and syringe exchange presence (2000) with CDC data on AIDS incidence and mortality among heterosexuals in 2006-2008, with appropriate socioeconomic controls. Results: Population density of HIV+ PWID and of NIDUs were positively related, and prevention programs for PWID negatively related to later AIDS incidence among heterosexuals and later mortality among heterosexuals living with AIDS. HIV+ MSM population density and prevention programs for MSM were not associated with these outcomes. Conclusions: Efforts to reduce HIV transmission among PWID and NIDUs may reduce AIDS and AIDS-related mortality among heterosexuals. More research is needed at metropolitan area, network, and individual levels into HIV bridging across key populations and how interventions in one key population affect HIV epidemics in other key populations.

AB - Purpose: We focus on a little-researched issue-how human immunodeficiency virus (HIV) epidemics and programs in key populations in metropolitan areas affect epidemics in other key populations. We consider (1) How are earlier epidemics among people who inject drugs (PWID) and men who have sex with men (MSM) related to later AIDS incidence and mortality among heterosexuals?; (2) Were prevention programs targeting PWID or MSM associated with lower AIDS incidence and mortality among heterosexuals?; and (3) Was the size of the potential bridge population of noninjecting drug users (NIDUs) in a metropolitan area associated with later AIDS incidence and mortality among heterosexuals? Methods: Using data for 96 large U.S. metropolitan areas, Poisson regression assessed associations of population prevalences of HIV-infected PWID and MSM (1992); NIDU population prevalence (1992-1994); drug use treatment coverage for PWID (1993); HIV counseling and testing coverage for MSM and for PWID (1992); and syringe exchange presence (2000) with CDC data on AIDS incidence and mortality among heterosexuals in 2006-2008, with appropriate socioeconomic controls. Results: Population density of HIV+ PWID and of NIDUs were positively related, and prevention programs for PWID negatively related to later AIDS incidence among heterosexuals and later mortality among heterosexuals living with AIDS. HIV+ MSM population density and prevention programs for MSM were not associated with these outcomes. Conclusions: Efforts to reduce HIV transmission among PWID and NIDUs may reduce AIDS and AIDS-related mortality among heterosexuals. More research is needed at metropolitan area, network, and individual levels into HIV bridging across key populations and how interventions in one key population affect HIV epidemics in other key populations.

KW - Bridging

KW - Epidemics

KW - Heterosexuals

KW - HIV/AIDS

KW - IDU

KW - Men who have sex with men

KW - Metropolitan areas

KW - MSM

KW - People who inject drugs

KW - Urban health

UR - http://www.scopus.com/inward/record.url?scp=84895437195&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895437195&partnerID=8YFLogxK

U2 - 10.1016/j.annepidem.2014.01.008

DO - 10.1016/j.annepidem.2014.01.008

M3 - Article

VL - 24

SP - 304

EP - 311

JO - Annals of Epidemiology

JF - Annals of Epidemiology

SN - 1047-2797

IS - 4

ER -