DNA cruciforms

Neville R. Kallenbach, Min Zhong

Research output: Contribution to journalArticle

Abstract

Cruciforms represent a novel DNA state with unique physical and biological properties, including the ability to undergo branch migration in appropriate sequence backgrounds. Recent results establish a preferred geometry of immobile cruciforms in Mg2+ solution, the rate of branch migration, and the binding properties of cruciforms for proteins and small molecule ligands. A structure has been determined for three-arm branches with unpaired bases at the branch.

Original languageEnglish (US)
Pages (from-to)365-371
Number of pages7
JournalCurrent Opinion in Structural Biology
Volume4
Issue number3
DOIs
StatePublished - Jun 1994

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ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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