Distribution of β-1 integrin in the developing rat heart

W. Carver, R. L. Price, D. S. Raso, Louis Terracio, T. K. Borg

Research output: Contribution to journalArticle

Abstract

Cell-cell and cell-matrix interactions play critical roles in various developmental processes including differentiation, proliferation, and migration. Members of the integrin family of cell surface components are important mediators of these cell-extracellular matrix (ECM) contacts or interactions. The ECM provides signals to individual cells essential for development and differentiation and plays essential roles in establishing and maintaining the complex structure of the vertebrate heart. Integrins provide a fundamental link for transduction of developmental signals to cells. Integrin expression by cardiac myocytes is altered during neonatal heart development and disease; however, little is known regarding the spatial and temporal patterns of integrin expression during embryonic and fetal heart development. Essential to understanding the role of integrins in the organization of the heart, the present studies have localized β-1 integrin protein and mRNA in fetal and neonatal rat hearts. β-1 integrin is predominantly found in regions of remodeling (trabeculae) in the early heart (10-13 days of gestation). Later in development (15 days of gestation onward), β-1 integrin is abundant in regions containing an elaborate ECM, such as the valves. These studies further support the hypothesis that the expressions of integrins and ECM are coordinately regulated in the developing heart.

Original languageEnglish (US)
Pages (from-to)167-175
Number of pages9
JournalJournal of Histochemistry and Cytochemistry
Volume42
Issue number2
StatePublished - 1994

Fingerprint

Integrins
Extracellular Matrix
Embryonic and Fetal Development
Fetal Heart
Pregnancy
Cellular Structures
Cardiac Myocytes
Cell Communication
Vertebrates
Heart Diseases
Signal Transduction
Organizations
Messenger RNA

Keywords

  • Development
  • Heart
  • Immunoelectron microscopy
  • Immunohistochemistry
  • Integrin
  • mRNA analysis

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy

Cite this

Carver, W., Price, R. L., Raso, D. S., Terracio, L., & Borg, T. K. (1994). Distribution of β-1 integrin in the developing rat heart. Journal of Histochemistry and Cytochemistry, 42(2), 167-175.

Distribution of β-1 integrin in the developing rat heart. / Carver, W.; Price, R. L.; Raso, D. S.; Terracio, Louis; Borg, T. K.

In: Journal of Histochemistry and Cytochemistry, Vol. 42, No. 2, 1994, p. 167-175.

Research output: Contribution to journalArticle

Carver, W, Price, RL, Raso, DS, Terracio, L & Borg, TK 1994, 'Distribution of β-1 integrin in the developing rat heart', Journal of Histochemistry and Cytochemistry, vol. 42, no. 2, pp. 167-175.
Carver, W. ; Price, R. L. ; Raso, D. S. ; Terracio, Louis ; Borg, T. K. / Distribution of β-1 integrin in the developing rat heart. In: Journal of Histochemistry and Cytochemistry. 1994 ; Vol. 42, No. 2. pp. 167-175.
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