Distinct visual pathways mediate drosophila larval light avoidance and circadian clock entrainment

Alex C. Keene, Esteban O. Mazzoni, Jamie Zhen, Meg A. Younger, Satoko Yamaguchi, Justin Blau, Claude Desplan, Simon G. Sprecher

Research output: Contribution to journalArticle

Abstract

Visual organs perceive environmental stimuli required for rapid initiation of behaviors and can also entrain the circadian clock. The larval eye of Drosophila is capable of both functions. Each eye contains only 12 photoreceptors (PRs), which can be subdivided into two subtypes. Four PRs express blue-sensitive rhodopsin5 (rh5) and eight express green-sensitive rhodopsin6 (rh6). We found that either PR-subtype is sufficient to entrain the molecular clock by light, while only the Rh5-PR subtype is essential for light avoidance. Acetylcholine released from PRs confers both functions. Both subtypes of larval PRs innervate the main circadian pacemaker neurons of the larva, the neuropeptide PDF (pigment-dispersing factor)-expressing lateral neurons (LNs), providing sensory input to control circadian rhythms. However, we show that PDF-expressing LNs are dispensable for light avoidance, and a distinct set of three clock neurons is required. Thus we have identified distinct sensory and central circuitry regulating light avoidance behavior and clock entrainment.Our findings provide insights into the coding of sensory information for distinct behavioral functions and the underlying molecular and neuronal circuitry.

Original languageEnglish (US)
Pages (from-to)6527-6534
Number of pages8
JournalJournal of Neuroscience
Volume31
Issue number17
DOIs
StatePublished - Apr 27 2011

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Circadian Clocks
Visual Pathways
Drosophila
Light
Neurons
Avoidance Learning
Sensory Receptor Cells
Circadian Rhythm
Neuropeptides
Acetylcholine
Larva

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Distinct visual pathways mediate drosophila larval light avoidance and circadian clock entrainment. / Keene, Alex C.; Mazzoni, Esteban O.; Zhen, Jamie; Younger, Meg A.; Yamaguchi, Satoko; Blau, Justin; Desplan, Claude; Sprecher, Simon G.

In: Journal of Neuroscience, Vol. 31, No. 17, 27.04.2011, p. 6527-6534.

Research output: Contribution to journalArticle

Keene, Alex C. ; Mazzoni, Esteban O. ; Zhen, Jamie ; Younger, Meg A. ; Yamaguchi, Satoko ; Blau, Justin ; Desplan, Claude ; Sprecher, Simon G. / Distinct visual pathways mediate drosophila larval light avoidance and circadian clock entrainment. In: Journal of Neuroscience. 2011 ; Vol. 31, No. 17. pp. 6527-6534.
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