Distinct roles of eicosanoids in the immune response to viral encephalitis

Or why you should take NSAIDs

Research output: Contribution to journalArticle

Abstract

Prostaglandins (PGs) and leukotrienes (LTs) are important proinflammatory mediators. They are both derived from arachidonic acid (AA). Cyclooxygenase (COX), the key enzyme in transforming AA into PGs, has two isoforms: COX-1 is constitutively expressed, and COX-2, is inducible. Lipoxygenase (5-LO) is the key enzyme for LT production. PGs and LTs have been intensively studied. Release of these molecules is associated with mucus secretion, redness, pain, fever and other inflammatory manifestations. Both PGs and LTs are involved in host defense against various pathogens. In addition to mediating inflammatory symptoms, PGs might suppress some innate immune factors, including nitric oxide (NO) production. PGs also suppress a TH1 response. LTs have pathologic potential, especially in asthma. LTs also have been found to have positive roles in host defense, either against virus or bacteria. Finally, PGs and LTs might regulate the production of each other, possibly at the level of substrate competition by their enzymes. Because they are clinically important molecules, a further understanding of the roles that PGs and LTs played in host defense will have great impact on therapeutic research.

Original languageEnglish (US)
Pages (from-to)133-146
Number of pages14
JournalViral Immunology
Volume15
Issue number1
StatePublished - 2002

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Viral Encephalitis
Eicosanoids
Leukotrienes
Non-Steroidal Anti-Inflammatory Agents
Prostaglandins
Arachidonic Acid
Enzymes
Therapeutic Human Experimentation
Arachidonate 5-Lipoxygenase
Cyclooxygenase 1
Immunologic Factors
Cyclooxygenase 2
Mucus
Prostaglandin-Endoperoxide Synthases
Nitric Oxide
Protein Isoforms
Fever
Asthma
Viruses
Bacteria

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Distinct roles of eicosanoids in the immune response to viral encephalitis : Or why you should take NSAIDs. / Chen, Nannan; Reiss, Carol Shoshkes.

In: Viral Immunology, Vol. 15, No. 1, 2002, p. 133-146.

Research output: Contribution to journalArticle

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