Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly

Jianmin Chen, Sandy Chang, Stephen A. Duncan, Hirotaka J. Okano, Gordon Fishell, Alan Aderem

    Research output: Contribution to journalArticle

    Abstract

    MacMARCKS is a member of the MARCKS family of protein kinase C (PKC) substrates. Biochemical evidence demonstrates that these proteins integrate calcium and PKC-dependent signals to regulate actin structure at the membrane. We report here that deletion of the MacMARCKS gene prevents cranial neural tube closure in the developing brain, resulting in anencephaly. This suggests a central role for MacMARCKS and the PKC signal transduction pathway in the folding of the anterior neural plate during the early phases of brain formation, and supports the hypothesis that actin-based motility directs cranial neural tube closure.

    Original languageEnglish (US)
    Pages (from-to)6275-6279
    Number of pages5
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume93
    Issue number13
    DOIs
    StatePublished - Jun 25 1996

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    Anencephaly
    Neural Tube
    Protein Kinase C
    Actins
    Genes
    Neural Plate
    Gene Deletion
    Brain
    Signal Transduction
    Calcium
    Membranes
    Proteins

    ASJC Scopus subject areas

    • General

    Cite this

    Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly. / Chen, Jianmin; Chang, Sandy; Duncan, Stephen A.; Okano, Hirotaka J.; Fishell, Gordon; Aderem, Alan.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, No. 13, 25.06.1996, p. 6275-6279.

    Research output: Contribution to journalArticle

    Chen, Jianmin ; Chang, Sandy ; Duncan, Stephen A. ; Okano, Hirotaka J. ; Fishell, Gordon ; Aderem, Alan. / Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly. In: Proceedings of the National Academy of Sciences of the United States of America. 1996 ; Vol. 93, No. 13. pp. 6275-6279.
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