Disrupting the memory of places induced by drugs of abuse weakens motivational withdrawal in a context-dependent manner

Stephen M. Taubenfeld, Elizaveta V. Muravieva, Ana Garcia-Osta, Cristina Alberini

Research output: Contribution to journalArticle

Abstract

Addicts repeatedly relapse to drug seeking even after years of abstinence, and this behavior is frequently induced by the recall of memories of the rewarding effects of the drug. Established memories, including those induced by drugs of abuse, can become transiently fragile if reactivated, and during this labile phase, known as reconsolidation, can be persistently disrupted. Here we show that, in rats, a morphine-induced place preference (mCPP) memory is linked to context-dependent withdrawal as disrupting the reconsolidation of the memory leads to a significant reduction of withdrawal evoked in the same context. Moreover, the hippocampus plays a critical role in linking the place preference memory with the context-conditioned withdrawal, as disrupting hippocampal protein synthesis and cAMP-dependent-protein kinase A after the reactivation of mCPP significantly weakens the withdrawal. Hence, targeting memories induced by drugs may represent an important strategy for attenuating context-conditioned withdrawal and therefore subsequent relapse in opiate addicts.

Original languageEnglish (US)
Pages (from-to)12345-12350
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number27
DOIs
StatePublished - Jul 6 2010

Fingerprint

Street Drugs
Cyclic AMP-Dependent Protein Kinases
Morphine
Opiate Alkaloids
Pharmaceutical Preparations
Recurrence
Hippocampus
Proteins

Keywords

  • Addiction
  • Hippocampus morphine
  • Reconsolidation

ASJC Scopus subject areas

  • General

Cite this

Disrupting the memory of places induced by drugs of abuse weakens motivational withdrawal in a context-dependent manner. / Taubenfeld, Stephen M.; Muravieva, Elizaveta V.; Garcia-Osta, Ana; Alberini, Cristina.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 27, 06.07.2010, p. 12345-12350.

Research output: Contribution to journalArticle

@article{fe7237ec2cc24802b9b94cea9a17dfe5,
title = "Disrupting the memory of places induced by drugs of abuse weakens motivational withdrawal in a context-dependent manner",
abstract = "Addicts repeatedly relapse to drug seeking even after years of abstinence, and this behavior is frequently induced by the recall of memories of the rewarding effects of the drug. Established memories, including those induced by drugs of abuse, can become transiently fragile if reactivated, and during this labile phase, known as reconsolidation, can be persistently disrupted. Here we show that, in rats, a morphine-induced place preference (mCPP) memory is linked to context-dependent withdrawal as disrupting the reconsolidation of the memory leads to a significant reduction of withdrawal evoked in the same context. Moreover, the hippocampus plays a critical role in linking the place preference memory with the context-conditioned withdrawal, as disrupting hippocampal protein synthesis and cAMP-dependent-protein kinase A after the reactivation of mCPP significantly weakens the withdrawal. Hence, targeting memories induced by drugs may represent an important strategy for attenuating context-conditioned withdrawal and therefore subsequent relapse in opiate addicts.",
keywords = "Addiction, Hippocampus morphine, Reconsolidation",
author = "Taubenfeld, {Stephen M.} and Muravieva, {Elizaveta V.} and Ana Garcia-Osta and Cristina Alberini",
year = "2010",
month = "7",
day = "6",
doi = "10.1073/pnas.1003152107",
language = "English (US)",
volume = "107",
pages = "12345--12350",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "27",

}

TY - JOUR

T1 - Disrupting the memory of places induced by drugs of abuse weakens motivational withdrawal in a context-dependent manner

AU - Taubenfeld, Stephen M.

AU - Muravieva, Elizaveta V.

AU - Garcia-Osta, Ana

AU - Alberini, Cristina

PY - 2010/7/6

Y1 - 2010/7/6

N2 - Addicts repeatedly relapse to drug seeking even after years of abstinence, and this behavior is frequently induced by the recall of memories of the rewarding effects of the drug. Established memories, including those induced by drugs of abuse, can become transiently fragile if reactivated, and during this labile phase, known as reconsolidation, can be persistently disrupted. Here we show that, in rats, a morphine-induced place preference (mCPP) memory is linked to context-dependent withdrawal as disrupting the reconsolidation of the memory leads to a significant reduction of withdrawal evoked in the same context. Moreover, the hippocampus plays a critical role in linking the place preference memory with the context-conditioned withdrawal, as disrupting hippocampal protein synthesis and cAMP-dependent-protein kinase A after the reactivation of mCPP significantly weakens the withdrawal. Hence, targeting memories induced by drugs may represent an important strategy for attenuating context-conditioned withdrawal and therefore subsequent relapse in opiate addicts.

AB - Addicts repeatedly relapse to drug seeking even after years of abstinence, and this behavior is frequently induced by the recall of memories of the rewarding effects of the drug. Established memories, including those induced by drugs of abuse, can become transiently fragile if reactivated, and during this labile phase, known as reconsolidation, can be persistently disrupted. Here we show that, in rats, a morphine-induced place preference (mCPP) memory is linked to context-dependent withdrawal as disrupting the reconsolidation of the memory leads to a significant reduction of withdrawal evoked in the same context. Moreover, the hippocampus plays a critical role in linking the place preference memory with the context-conditioned withdrawal, as disrupting hippocampal protein synthesis and cAMP-dependent-protein kinase A after the reactivation of mCPP significantly weakens the withdrawal. Hence, targeting memories induced by drugs may represent an important strategy for attenuating context-conditioned withdrawal and therefore subsequent relapse in opiate addicts.

KW - Addiction

KW - Hippocampus morphine

KW - Reconsolidation

UR - http://www.scopus.com/inward/record.url?scp=77955448691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955448691&partnerID=8YFLogxK

U2 - 10.1073/pnas.1003152107

DO - 10.1073/pnas.1003152107

M3 - Article

C2 - 20566855

AN - SCOPUS:77955448691

VL - 107

SP - 12345

EP - 12350

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 27

ER -