Dispersion of neural progenitors within the germinal zones of the forebrain

Gordon Fishell, Carol A. Mason, Mary E. Hatten

    Research output: Contribution to journalArticle

    Abstract

    One of the early events in the establishment of regional diversity in brain is the subdivision of the forebrain into the cerebral cortex1-7 and underlying basal ganglia8. This subdivision is of special interest, owing to the striking difference in cellular patterning in these two regions. Whereas the dorsal aspect of the telencephalon gives rise to the laminar, cortical regions of brain, the basal aspect gives rise to nuclear, subcortical regions. To examine early events in the regionalization of the forebrain, we visualized cell movement within the ventricular zones of the dorsal and basal regions of the E15 murine telencephalon. Over an 8-24-hour observation period, labelled cells moved extensively in the plane of the cortical ventricular zone. Cell dispersion was restricted, however, at the border between the cortical ventricular zone and the lateral ganglionic eminence, the basal telencephalic ventricular zone. We suggest that this restriction of cell movements establishes a regional pattern of neurogenesis in the developing brain.

    Original languageEnglish (US)
    Pages (from-to)636-638
    Number of pages3
    JournalNature
    Volume362
    Issue number6421
    DOIs
    StatePublished - Jan 1 1993

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    Telencephalon
    Prosencephalon
    Cell Movement
    Brain
    Neurogenesis
    Observation

    ASJC Scopus subject areas

    • General

    Cite this

    Dispersion of neural progenitors within the germinal zones of the forebrain. / Fishell, Gordon; Mason, Carol A.; Hatten, Mary E.

    In: Nature, Vol. 362, No. 6421, 01.01.1993, p. 636-638.

    Research output: Contribution to journalArticle

    Fishell, G, Mason, CA & Hatten, ME 1993, 'Dispersion of neural progenitors within the germinal zones of the forebrain', Nature, vol. 362, no. 6421, pp. 636-638. https://doi.org/10.1038/362636a0
    Fishell, Gordon ; Mason, Carol A. ; Hatten, Mary E. / Dispersion of neural progenitors within the germinal zones of the forebrain. In: Nature. 1993 ; Vol. 362, No. 6421. pp. 636-638.
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