Disorders of compulsivity: A common bias towards learning habits

V. Voon, K. Derbyshire, C. Rück, M. A. Irvine, Y. Worbe, J. Enander, L. R N Schreiber, C. Gillan, N. A. Fineberg, B. J. Sahakian, T. W. Robbins, N. A. Harrison, J. Wood, N. D. Daw, P. Dayan, J. E. Grant, E. T. Bullmore

Research output: Contribution to journalArticle

Abstract

Why do we repeat choices that we know are bad for us? Decision making is characterized by the parallel engagement of two distinct systems, goal-directed and habitual, thought to arise from two computational learning mechanisms, model-based and model-free. The habitual system is a candidate source of pathological fixedness. Using a decision task that measures the contribution to learning of either mechanism, we show a bias towards model-free (habit) acquisition in disorders involving both natural (binge eating) and artificial (methamphetamine) rewards, and obsessive-compulsive disorder. This favoring of model-free learning may underlie the repetitive behaviors that ultimately dominate in these disorders. Further, we show that the habit formation bias is associated with lower gray matter volumes in caudate and medial orbitofrontal cortex. Our findings suggest that the dysfunction in a common neurocomputational mechanism may underlie diverse disorders involving compulsion.

Original languageEnglish (US)
Pages (from-to)345-352
Number of pages8
JournalMolecular Psychiatry
Volume20
Issue number3
DOIs
StatePublished - Mar 12 2015

Fingerprint

Habits
Learning
Bulimia
Methamphetamine
Obsessive-Compulsive Disorder
Prefrontal Cortex
Reward
Decision Making
Gray Matter

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Voon, V., Derbyshire, K., Rück, C., Irvine, M. A., Worbe, Y., Enander, J., ... Bullmore, E. T. (2015). Disorders of compulsivity: A common bias towards learning habits. Molecular Psychiatry, 20(3), 345-352. https://doi.org/10.1038/mp.2014.44

Disorders of compulsivity : A common bias towards learning habits. / Voon, V.; Derbyshire, K.; Rück, C.; Irvine, M. A.; Worbe, Y.; Enander, J.; Schreiber, L. R N; Gillan, C.; Fineberg, N. A.; Sahakian, B. J.; Robbins, T. W.; Harrison, N. A.; Wood, J.; Daw, N. D.; Dayan, P.; Grant, J. E.; Bullmore, E. T.

In: Molecular Psychiatry, Vol. 20, No. 3, 12.03.2015, p. 345-352.

Research output: Contribution to journalArticle

Voon, V, Derbyshire, K, Rück, C, Irvine, MA, Worbe, Y, Enander, J, Schreiber, LRN, Gillan, C, Fineberg, NA, Sahakian, BJ, Robbins, TW, Harrison, NA, Wood, J, Daw, ND, Dayan, P, Grant, JE & Bullmore, ET 2015, 'Disorders of compulsivity: A common bias towards learning habits', Molecular Psychiatry, vol. 20, no. 3, pp. 345-352. https://doi.org/10.1038/mp.2014.44
Voon V, Derbyshire K, Rück C, Irvine MA, Worbe Y, Enander J et al. Disorders of compulsivity: A common bias towards learning habits. Molecular Psychiatry. 2015 Mar 12;20(3):345-352. https://doi.org/10.1038/mp.2014.44
Voon, V. ; Derbyshire, K. ; Rück, C. ; Irvine, M. A. ; Worbe, Y. ; Enander, J. ; Schreiber, L. R N ; Gillan, C. ; Fineberg, N. A. ; Sahakian, B. J. ; Robbins, T. W. ; Harrison, N. A. ; Wood, J. ; Daw, N. D. ; Dayan, P. ; Grant, J. E. ; Bullmore, E. T. / Disorders of compulsivity : A common bias towards learning habits. In: Molecular Psychiatry. 2015 ; Vol. 20, No. 3. pp. 345-352.
@article{33cc91e9dfc14560ac827e6e9137df5c,
title = "Disorders of compulsivity: A common bias towards learning habits",
abstract = "Why do we repeat choices that we know are bad for us? Decision making is characterized by the parallel engagement of two distinct systems, goal-directed and habitual, thought to arise from two computational learning mechanisms, model-based and model-free. The habitual system is a candidate source of pathological fixedness. Using a decision task that measures the contribution to learning of either mechanism, we show a bias towards model-free (habit) acquisition in disorders involving both natural (binge eating) and artificial (methamphetamine) rewards, and obsessive-compulsive disorder. This favoring of model-free learning may underlie the repetitive behaviors that ultimately dominate in these disorders. Further, we show that the habit formation bias is associated with lower gray matter volumes in caudate and medial orbitofrontal cortex. Our findings suggest that the dysfunction in a common neurocomputational mechanism may underlie diverse disorders involving compulsion.",
author = "V. Voon and K. Derbyshire and C. R{\"u}ck and Irvine, {M. A.} and Y. Worbe and J. Enander and Schreiber, {L. R N} and C. Gillan and Fineberg, {N. A.} and Sahakian, {B. J.} and Robbins, {T. W.} and Harrison, {N. A.} and J. Wood and Daw, {N. D.} and P. Dayan and Grant, {J. E.} and Bullmore, {E. T.}",
year = "2015",
month = "3",
day = "12",
doi = "10.1038/mp.2014.44",
language = "English (US)",
volume = "20",
pages = "345--352",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Disorders of compulsivity

T2 - A common bias towards learning habits

AU - Voon, V.

AU - Derbyshire, K.

AU - Rück, C.

AU - Irvine, M. A.

AU - Worbe, Y.

AU - Enander, J.

AU - Schreiber, L. R N

AU - Gillan, C.

AU - Fineberg, N. A.

AU - Sahakian, B. J.

AU - Robbins, T. W.

AU - Harrison, N. A.

AU - Wood, J.

AU - Daw, N. D.

AU - Dayan, P.

AU - Grant, J. E.

AU - Bullmore, E. T.

PY - 2015/3/12

Y1 - 2015/3/12

N2 - Why do we repeat choices that we know are bad for us? Decision making is characterized by the parallel engagement of two distinct systems, goal-directed and habitual, thought to arise from two computational learning mechanisms, model-based and model-free. The habitual system is a candidate source of pathological fixedness. Using a decision task that measures the contribution to learning of either mechanism, we show a bias towards model-free (habit) acquisition in disorders involving both natural (binge eating) and artificial (methamphetamine) rewards, and obsessive-compulsive disorder. This favoring of model-free learning may underlie the repetitive behaviors that ultimately dominate in these disorders. Further, we show that the habit formation bias is associated with lower gray matter volumes in caudate and medial orbitofrontal cortex. Our findings suggest that the dysfunction in a common neurocomputational mechanism may underlie diverse disorders involving compulsion.

AB - Why do we repeat choices that we know are bad for us? Decision making is characterized by the parallel engagement of two distinct systems, goal-directed and habitual, thought to arise from two computational learning mechanisms, model-based and model-free. The habitual system is a candidate source of pathological fixedness. Using a decision task that measures the contribution to learning of either mechanism, we show a bias towards model-free (habit) acquisition in disorders involving both natural (binge eating) and artificial (methamphetamine) rewards, and obsessive-compulsive disorder. This favoring of model-free learning may underlie the repetitive behaviors that ultimately dominate in these disorders. Further, we show that the habit formation bias is associated with lower gray matter volumes in caudate and medial orbitofrontal cortex. Our findings suggest that the dysfunction in a common neurocomputational mechanism may underlie diverse disorders involving compulsion.

UR - http://www.scopus.com/inward/record.url?scp=84924655858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924655858&partnerID=8YFLogxK

U2 - 10.1038/mp.2014.44

DO - 10.1038/mp.2014.44

M3 - Article

AN - SCOPUS:84924655858

VL - 20

SP - 345

EP - 352

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

IS - 3

ER -