Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold

Lun K. Tsou, Ginger E. Dutschman, Elizabeth A. Gullen, Maria Telpoukhovskaia, Yung C. Cheng, Andrew Hamilton

Research output: Contribution to journal › Article

Abstract

A potential anti-HIV and HCV drug candidate is highly desirable as coinfection has become a worldwide public health challenge. A potent compound based on a tetrabutoxy-calix[4]arene scaffold that possesses dual inhibition for both HIV and HCV is described. Structural activity relationship studies demonstrate the effects of lower-rim alkylation in maintaining cone conformation and upper-rim interacting head groups on the calix[4]arene play key roles for its potent dual antiviral activities.

Original languageEnglish (US)
Pages (from-to)2137-2139
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number7
DOIs
StatePublished - Apr 1 2010

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Scaffolds
HIV Infections
Anti-HIV Agents
Alkylation
Public health
Coinfection
Antiviral Agents
Conformations
Cones
Public Health
Head
HIV
Pharmaceutical Preparations
calix(4)arene
Global Health

Keywords

  • Calixarenes
  • HIV-HCV coinfection inhibitors
  • Protein surface recognition

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold. / Tsou, Lun K.; Dutschman, Ginger E.; Gullen, Elizabeth A.; Telpoukhovskaia, Maria; Cheng, Yung C.; Hamilton, Andrew.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 7, 01.04.2010, p. 2137-2139.

Research output: Contribution to journal › Article

Tsou, LK, Dutschman, GE, Gullen, EA, Telpoukhovskaia, M, Cheng, YC & Hamilton, A 2010, 'Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold', Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 7, pp. 2137-2139. https://doi.org/10.1016/j.bmcl.2010.02.043
Tsou LK, Dutschman GE, Gullen EA, Telpoukhovskaia M, Cheng YC, Hamilton A. Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold. Bioorganic and Medicinal Chemistry Letters. 2010 Apr 1;20(7):2137-2139. https://doi.org/10.1016/j.bmcl.2010.02.043
Tsou, Lun K. ; Dutschman, Ginger E. ; Gullen, Elizabeth A. ; Telpoukhovskaia, Maria ; Cheng, Yung C. ; Hamilton, Andrew. / Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold. In: Bioorganic and Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 7. pp. 2137-2139.
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