Abstract
A potential anti-HIV and HCV drug candidate is highly desirable as coinfection has become a worldwide public health challenge. A potent compound based on a tetrabutoxy-calix[4]arene scaffold that possesses dual inhibition for both HIV and HCV is described. Structural activity relationship studies demonstrate the effects of lower-rim alkylation in maintaining cone conformation and upper-rim interacting head groups on the calix[4]arene play key roles for its potent dual antiviral activities.
Original language | English (US) |
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Pages (from-to) | 2137-2139 |
Number of pages | 3 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 20 |
Issue number | 7 |
DOIs | |
State | Published - Apr 1 2010 |
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Keywords
- Calixarenes
- HIV-HCV coinfection inhibitors
- Protein surface recognition
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Molecular Biology
- Molecular Medicine
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold. / Tsou, Lun K.; Dutschman, Ginger E.; Gullen, Elizabeth A.; Telpoukhovskaia, Maria; Cheng, Yung C.; Hamilton, Andrew.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 7, 01.04.2010, p. 2137-2139.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold
AU - Tsou, Lun K.
AU - Dutschman, Ginger E.
AU - Gullen, Elizabeth A.
AU - Telpoukhovskaia, Maria
AU - Cheng, Yung C.
AU - Hamilton, Andrew
PY - 2010/4/1
Y1 - 2010/4/1
N2 - A potential anti-HIV and HCV drug candidate is highly desirable as coinfection has become a worldwide public health challenge. A potent compound based on a tetrabutoxy-calix[4]arene scaffold that possesses dual inhibition for both HIV and HCV is described. Structural activity relationship studies demonstrate the effects of lower-rim alkylation in maintaining cone conformation and upper-rim interacting head groups on the calix[4]arene play key roles for its potent dual antiviral activities.
AB - A potential anti-HIV and HCV drug candidate is highly desirable as coinfection has become a worldwide public health challenge. A potent compound based on a tetrabutoxy-calix[4]arene scaffold that possesses dual inhibition for both HIV and HCV is described. Structural activity relationship studies demonstrate the effects of lower-rim alkylation in maintaining cone conformation and upper-rim interacting head groups on the calix[4]arene play key roles for its potent dual antiviral activities.
KW - Calixarenes
KW - HIV-HCV coinfection inhibitors
KW - Protein surface recognition
UR - http://www.scopus.com/inward/record.url?scp=77949484705&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949484705&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2010.02.043
DO - 10.1016/j.bmcl.2010.02.043
M3 - Article
C2 - 20202840
AN - SCOPUS:77949484705
VL - 20
SP - 2137
EP - 2139
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 7
ER -