Discordant phylogeographic patterns between the Y chromosome and mitochondrial DNA in the house mouse

Selection on the Y chromosome?

Stephane Boissinot, Pierre Boursot

    Research output: Contribution to journalArticle

    Abstract

    We have compared patterns of geographic variation and molecular divergence of mitochondrial DNA (mtDNA) and Y chromosome over the range of the different subspecies of Mus musculus. MtDNA was typed for 305 nucleotides in the control region, the Y chromosome for 834 based pairs (bp) in Zfy introns and 242 bp in Sry, a Zfy2 18-bp deletion, and two microsatellites. Apparent discrepancies exist between the distributions of the lineages of mtDNA and of the two major Y-chromosome lineages thus defined: some subspecies share the same mtDNA lineage but have different Y-chromosome lineages or vice versa. One microsatellite reveals a geographically clustered variation inside the distribution of each Y-chromosome lineage, showing that new Y-chromosome variants can rapidly spread locally. The two major Y- chromosome lineages have a divergence time only about one fourth of that between mtDNA lineages. Although this recent coalescence of the Y chromosomes between subspecies could partly be due to a lower ancestral polymorphism of the Y chromosome, it suggests that secondary introgression after the radiation of the subspecies might have occurred. There is evidence that the differentiation of the Y-chromosome lineages contributes to partial reproductive isolation between subspecies, and patterns of molecular evolution suggest that selection has played a role in the rapid spread across subspecies.

    Original languageEnglish (US)
    Pages (from-to)1019-1034
    Number of pages16
    JournalGenetics
    Volume146
    Issue number3
    StatePublished - Jul 23 1997

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    Y Chromosome
    Mitochondrial DNA
    Microsatellite Repeats
    Reproductive Isolation
    Molecular Evolution
    Introns
    Nucleotides
    Radiation

    ASJC Scopus subject areas

    • Genetics

    Cite this

    Discordant phylogeographic patterns between the Y chromosome and mitochondrial DNA in the house mouse : Selection on the Y chromosome? / Boissinot, Stephane; Boursot, Pierre.

    In: Genetics, Vol. 146, No. 3, 23.07.1997, p. 1019-1034.

    Research output: Contribution to journalArticle

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