Discordance of prenatal and neonatal brain development in twins

Niyati Mukherjee, Chaeryon Kang, Honor M. Wolfe, Barbara S. Hertzberg, J. Keith Smith, Weili Lin, Guido Gerig, Robert M. Hamer, John H. Gilmore

    Research output: Contribution to journalArticle

    Abstract

    Background: Discordance of birth weight has been observed in twin pairs, though little is known about prenatal and early neonatal discordance of head and brain size, and the role that zygosity and chorionicity play in discordances of early brain development in twins. Aims: To compare prenatal and neonatal discordances of head size in monozygotic-monochorionic (MZ-MC), monozygotic-dichorionic (MZ-DC), and same-sex dizygotic-dichorionic twin pairs (DZ). Study design: Subjects prospectively had ultrasounds at 22 and 32 weeks gestational age, and magnetic resonance imaging (MRI) of the brain MRI after birth. Subjects: 88 twin pairs recruited from two university hospital prenatal diagnostic clinics; 22 MZ-MC, 17 MZ-DC, and 49 same-sex DZ pairs. Outcome measures: Discordance of head circumference (HC) and weight at 22 weeks, 32 weeks and birth, as well as intracranial volume (ICV) on neonatal MRI. Results: There were no group differences in discordance of head circumference and weight on the 22 or 32 week ultrasounds, or at birth. MZ-MC twins tended to have numerically greater discordances of HC and weight. There was a significant group difference in ICV on neonatal MRI (ANOVA, p = 0.0143), with DZ twins having significantly greater discordance than MZ-MC (p = 0.028) or MZ-DC (p = 0.0131) twins. Conclusions: This study indicates that zygosity and chorionicity do not contribute to significant discordances of head size in late prenatal development. DZ twins do have significantly greater discordances of ICV on neonatal MRI, suggesting a relatively greater genetic influence on brain growth in the first weeks after birth.

    Original languageEnglish (US)
    Pages (from-to)171-175
    Number of pages5
    JournalEarly Human Development
    Volume85
    Issue number3
    DOIs
    StatePublished - Mar 2009

    Fingerprint

    Head
    Magnetic Resonance Imaging
    Brain
    Parturition
    Weights and Measures
    Dizygotic Twins
    Monozygotic Twins
    Birth Weight
    Gestational Age
    Analysis of Variance
    Outcome Assessment (Health Care)
    Growth

    Keywords

    • Chorionicity
    • Magnetic resonance imaging
    • Ultrasound

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Obstetrics and Gynecology

    Cite this

    Mukherjee, N., Kang, C., Wolfe, H. M., Hertzberg, B. S., Smith, J. K., Lin, W., ... Gilmore, J. H. (2009). Discordance of prenatal and neonatal brain development in twins. Early Human Development, 85(3), 171-175. https://doi.org/10.1016/j.earlhumdev.2008.07.008

    Discordance of prenatal and neonatal brain development in twins. / Mukherjee, Niyati; Kang, Chaeryon; Wolfe, Honor M.; Hertzberg, Barbara S.; Smith, J. Keith; Lin, Weili; Gerig, Guido; Hamer, Robert M.; Gilmore, John H.

    In: Early Human Development, Vol. 85, No. 3, 03.2009, p. 171-175.

    Research output: Contribution to journalArticle

    Mukherjee, N, Kang, C, Wolfe, HM, Hertzberg, BS, Smith, JK, Lin, W, Gerig, G, Hamer, RM & Gilmore, JH 2009, 'Discordance of prenatal and neonatal brain development in twins', Early Human Development, vol. 85, no. 3, pp. 171-175. https://doi.org/10.1016/j.earlhumdev.2008.07.008
    Mukherjee N, Kang C, Wolfe HM, Hertzberg BS, Smith JK, Lin W et al. Discordance of prenatal and neonatal brain development in twins. Early Human Development. 2009 Mar;85(3):171-175. https://doi.org/10.1016/j.earlhumdev.2008.07.008
    Mukherjee, Niyati ; Kang, Chaeryon ; Wolfe, Honor M. ; Hertzberg, Barbara S. ; Smith, J. Keith ; Lin, Weili ; Gerig, Guido ; Hamer, Robert M. ; Gilmore, John H. / Discordance of prenatal and neonatal brain development in twins. In: Early Human Development. 2009 ; Vol. 85, No. 3. pp. 171-175.
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    AU - Smith, J. Keith

    AU - Lin, Weili

    AU - Gerig, Guido

    AU - Hamer, Robert M.

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