Directly reactivated, but not indirectly reactivated, memories undergo reconsolidation in the amygdala

Jacek Dȩbiec, Valérie Doyère, Karim Nader, Joseph Ledoux

Research output: Contribution to journalArticle

Abstract

Memory consolidation refers to a process by which newly learned information is made resistant to disruption. Traditionally, consolidation has been viewed as an event that occurs once in the life of a memory. However, considerable evidence now indicates that consolidated memories, when reactivated through retrieval, become labile (susceptible to disruption) again and undergo reconsolidation. Because memories are often interrelated in complex associative networks rather than stored in isolation, a key question is whether reactivation of one memory makes associated memories labile in a way that requires reconsolidation. We tested this in rats by creating interlinked associative memories using a second-order fear-conditioning task. We found that directly reactivated memories become labile, but indirectly reactivated (i.e., associated) memories do not. This suggests that memory reactivation produces content-limited rather than wholesale changes in a memory and its associations and explains why each time a memory is retrieved and updated, the entire associative structure of the memory is not grossly altered.

Original languageEnglish (US)
Pages (from-to)3428-3433
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number9
DOIs
Publication statusPublished - Feb 28 2006

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Keywords

  • Associative learning
  • Consolidation
  • Fear
  • Memory

ASJC Scopus subject areas

  • Genetics
  • General

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