Directed denaturation: Room temperature and stoichiometric unfolding of cytochrome c by a metalloporphyrin dimer

Andrew J. Wilson, Kevin Groves, Rishi K. Jain, Hyung Soon Park, Andrew D. Hamilton

Research output: Contribution to journalArticle

Abstract

Using circular dichroism, UV-vis, and trypsin proteolysis, we have shown how a metalloporphyrin dimer induces the unfolding of a protein, cytochrome c, under physiologically relevant conditions and accelerates its rate of proteolytic degradation.

Original languageEnglish (US)
Pages (from-to)4420-4421
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number15
DOIs
StatePublished - Apr 16 2003

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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