Abstract
The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6- disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an α-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.
Original language | English (US) |
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Pages (from-to) | 1751-1754 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 8 |
Issue number | 9 |
DOIs | |
State | Published - Apr 27 2006 |
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ASJC Scopus subject areas
- Molecular Medicine
Cite this
Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix. / Kim, In Chul; Hamilton, Andrew.
In: Organic Letters, Vol. 8, No. 9, 27.04.2006, p. 1751-1754.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix
AU - Kim, In Chul
AU - Hamilton, Andrew
PY - 2006/4/27
Y1 - 2006/4/27
N2 - The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6- disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an α-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.
AB - The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6- disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an α-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.
UR - http://www.scopus.com/inward/record.url?scp=33646450921&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646450921&partnerID=8YFLogxK
U2 - 10.1021/ol052956q
DO - 10.1021/ol052956q
M3 - Article
C2 - 16623542
AN - SCOPUS:33646450921
VL - 8
SP - 1751
EP - 1754
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 9
ER -