Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix

In Chul Kim, Andrew Hamilton

Research output: Contribution to journal › Article

Abstract

The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6- disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an α-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.

Original languageEnglish (US)
Pages (from-to)1751-1754
Number of pages4
JournalOrganic Letters
Volume8
Issue number9
DOIs
StatePublished - Apr 27 2006

Fingerprint

Scaffolds
helices
projection
Proteins
proteins
synthesis
diphenyl

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix. / Kim, In Chul; Hamilton, Andrew.

In: Organic Letters, Vol. 8, No. 9, 27.04.2006, p. 1751-1754.

Research output: Contribution to journal › Article

Kim, IC & Hamilton, A 2006, 'Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix', Organic Letters, vol. 8, no. 9, pp. 1751-1754. https://doi.org/10.1021/ol052956q
Kim IC, Hamilton A. Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix. Organic Letters. 2006 Apr 27;8(9):1751-1754. https://doi.org/10.1021/ol052956q
Kim, In Chul ; Hamilton, Andrew. / Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix. In: Organic Letters. 2006 ; Vol. 8, No. 9. pp. 1751-1754.
@article{b516037163f84745a64d96af3f63747d,
title = "Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix",
abstract = "The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6- disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an α-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.",
author = "Kim, {In Chul} and Andrew Hamilton",
year = "2006",
month = "4",
day = "27",
doi = "10.1021/ol052956q",
language = "English (US)",
volume = "8",
pages = "1751--1754",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "9",

}

TY - JOUR

T1 - Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix

AU - Kim, In Chul

AU - Hamilton, Andrew

PY - 2006/4/27

Y1 - 2006/4/27

N2 - The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6- disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an α-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.

AB - The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6- disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an α-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.

UR - http://www.scopus.com/inward/record.url?scp=33646450921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646450921&partnerID=8YFLogxK

U2 - 10.1021/ol052956q

DO - 10.1021/ol052956q

M3 - Article

C2 - 16623542

AN - SCOPUS:33646450921

VL - 8

SP - 1751

EP - 1754

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 9

ER -

Access to Document