Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix

In Chul Kim, Andrew Hamilton

Research output: Contribution to journal › Article

Abstract

The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6- disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an α-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.

Original languageEnglish (US)
Pages (from-to)1751-1754
Number of pages4
JournalOrganic Letters
Volume8
Issue number9
DOIs
StatePublished - Apr 27 2006

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Scaffolds
helices
projection
Proteins
proteins
synthesis
diphenyl

ASJC Scopus subject areas

  • Molecular Medicine

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Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix. / Kim, In Chul; Hamilton, Andrew.

In: Organic Letters, Vol. 8, No. 9, 27.04.2006, p. 1751-1754.

Research output: Contribution to journal › Article

Kim, IC & Hamilton, A 2006, 'Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix', Organic Letters, vol. 8, no. 9, pp. 1751-1754. https://doi.org/10.1021/ol052956q
Kim IC, Hamilton A. Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix. Organic Letters. 2006 Apr 27;8(9):1751-1754. https://doi.org/10.1021/ol052956q
Kim, In Chul ; Hamilton, Andrew. / Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix. In: Organic Letters. 2006 ; Vol. 8, No. 9. pp. 1751-1754.
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