Diminished behavioral and neural sensitivity to sound modulation is associated with moderate developmental hearing loss

Merri J. Rosen, Emma C. Sarro, Jack B. Kelly, Dan Sanes

Research output: Contribution to journalArticle

Abstract

The acoustic rearing environment can alter central auditory coding properties, yet altered neural coding is seldom linked with specific deficits to adult perceptual skills. To test whether developmental hearing loss resulted in comparable changes to perception and sensory coding, we examined behavioral and neural detection thresholds for sinusoidally amplitude modulated (sAM) stimuli. Behavioral sAM detection thresholds for slow (5 Hz) modulations were significantly worse for animals reared with bilateral conductive hearing loss (CHL), as compared to controls. This difference could not be attributed to hearing thresholds, proficiency at the task, or proxies for attention. Detection thresholds across the groups did not differ for fast (100 Hz) modulations, a result paralleling that seen in humans. Neural responses to sAM stimuli were recorded in single auditory cortex neurons from separate groups of awake animals. Neurometric analyses indicated equivalent thresholds for the most sensitive neurons, but a significantly poorer detection threshold for slow modulations across the population of CHL neurons as compared to controls. The magnitude of the neural deficit matched that of the behavioral differences, suggesting that a reduction of sensory information can account for limitations to perceptual skills.

Original languageEnglish (US)
Article numbere41514
JournalPLoS One
Volume7
Issue number7
DOIs
StatePublished - Jul 26 2012

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Audition
hearing
Hearing Loss
Conductive Hearing Loss
detection limit
Modulation
Acoustic waves
Neurons
neurons
Bilateral Hearing Loss
Animals
Auditory Cortex
Proxy
Acoustics
Hearing
acoustics
animals
cortex
rearing
Population

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Diminished behavioral and neural sensitivity to sound modulation is associated with moderate developmental hearing loss. / Rosen, Merri J.; Sarro, Emma C.; Kelly, Jack B.; Sanes, Dan.

In: PLoS One, Vol. 7, No. 7, e41514, 26.07.2012.

Research output: Contribution to journalArticle

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