Differential sensitivity to prevention programming: A dopaminergic polymorphism-enhanced prevention effect on protective parenting and adolescent substance use

Gene H. Brody, Yi fu Chen, Steven R H Beach, Steven M. Kogan, Tianyi Yu, Ralph DiClemente, Gina M. Wingood, Michael Windle, Robert A. Philibert

Research output: Contribution to journalArticle

Abstract

Objective: The purpose of this study was to investigate a genetic moderation effect of dopamine receptor-4 gene (DRD4) alleles that have 7 or more repeats on the efficacy of a preventive intervention to deter rural African American adolescents' substance use. Methods: Adolescents (N = 502, M age = 16 years) were assigned randomly to the Strong African American Families-Teen (SAAF-T) program or to a control condition and were followed for 22 months. Adolescents provided data on substance use, and both adolescents and their primary caregivers provided data on intervention-targeted protective parenting practices. Results: Male adolescents who carried at least one allele of DRD4 with 7 or more repeats who were assigned to the control condition evinced more substance use across 22 months than did (a) carriers of at least one allele of DRD4 with 7 or more repeats who were assigned to SAAF-T or (b) adolescents assigned to either condition who carried two alleles of DRD4 with 6 or fewer repeats. These findings were mediated by DRD4 × SAAF-T interaction effects on increases in intervention-targeted protective parenting practices, a mediated moderation effect. Conclusions: The results imply that prevention effects on health-relevant outcomes for genetically susceptible individuals, such as carriers of at least one allele of DRD4 with 7 or more repeats, may be underestimated.

Original languageEnglish (US)
Pages (from-to)182-191
Number of pages10
JournalHealth Psychology
Volume33
Issue number2
DOIs
StatePublished - Jan 1 2014

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Parenting
African Americans
Alleles
Dopamine Receptors
Caregivers
Health

Keywords

  • African american
  • Genetics
  • Intervention
  • Prevention
  • Substance use

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Differential sensitivity to prevention programming : A dopaminergic polymorphism-enhanced prevention effect on protective parenting and adolescent substance use. / Brody, Gene H.; Chen, Yi fu; Beach, Steven R H; Kogan, Steven M.; Yu, Tianyi; DiClemente, Ralph; Wingood, Gina M.; Windle, Michael; Philibert, Robert A.

In: Health Psychology, Vol. 33, No. 2, 01.01.2014, p. 182-191.

Research output: Contribution to journalArticle

Brody, Gene H. ; Chen, Yi fu ; Beach, Steven R H ; Kogan, Steven M. ; Yu, Tianyi ; DiClemente, Ralph ; Wingood, Gina M. ; Windle, Michael ; Philibert, Robert A. / Differential sensitivity to prevention programming : A dopaminergic polymorphism-enhanced prevention effect on protective parenting and adolescent substance use. In: Health Psychology. 2014 ; Vol. 33, No. 2. pp. 182-191.
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