Differential locus coeruleus and hypothalamic self-stimulation interactions

R. J. Bodnar, S. J. Ellman, Edgar Coons

Research output: Contribution to journalArticle

Abstract

To ascertain the nature of intracranial self-stimulation (ICSS) interactions between locus coeruleus (LC) and various hypothalamic (HYP) sites, rats were tested with monophasic pulse pair stimulation. When trains of pulse pairs were delivered to a single ICSS site, lower responding occurred at short pulse-pair intervals. However, when the pulses of each pulse pair were split between LC and HYP ICSS sites, response rates at all pulse-pair intervals were elevated well above single-pulse responding, indicating a neurophysiological interaction between these loci. The symmetry of LC and HYP interactions depended upon the HYP electrode placement. Both internal capsule and fields of Forel placements produced asymmetrical LC-HYP interactions in which higher ICSS rates occurred when the LC received the first pulse of each pair than when it received the second pulse of each pair, suggesting a direct, and possibly modulating, influence of the LC upon these HYP placements. Both medial forebrain bundle and perifornical HYP placements produced symmetrical LC-HYP interactions in which similar ICSS rates occurred regardless of site stimulation order, suggesting an indirect, reciprocal influence between the LC and these HYP placements.

Original languageEnglish (US)
Pages (from-to)269-277
Number of pages9
JournalPhysiological Psychology
Volume7
Issue number3
StatePublished - 1979

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Self Stimulation
Locus Coeruleus
Medial Forebrain Bundle
Internal Capsule
Electrodes

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Bodnar, R. J., Ellman, S. J., & Coons, E. (1979). Differential locus coeruleus and hypothalamic self-stimulation interactions. Physiological Psychology, 7(3), 269-277.

Differential locus coeruleus and hypothalamic self-stimulation interactions. / Bodnar, R. J.; Ellman, S. J.; Coons, Edgar.

In: Physiological Psychology, Vol. 7, No. 3, 1979, p. 269-277.

Research output: Contribution to journalArticle

Bodnar, RJ, Ellman, SJ & Coons, E 1979, 'Differential locus coeruleus and hypothalamic self-stimulation interactions', Physiological Psychology, vol. 7, no. 3, pp. 269-277.
Bodnar, R. J. ; Ellman, S. J. ; Coons, Edgar. / Differential locus coeruleus and hypothalamic self-stimulation interactions. In: Physiological Psychology. 1979 ; Vol. 7, No. 3. pp. 269-277.
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