Differential encoding of losses and gains in the human striatum

Ben Seymour, Nathaniel Daw, Peter Dayan, Tania Singer, Ray Dolan

Research output: Contribution to journalArticle

Abstract

Studies on human monetary prediction and decision making emphasize the role of the striatum in encoding prediction errors for financial reward. However, less is known about how the brain encodes financial loss. Using Pavlovian conditioning of visual cues to outcomes that simultaneously incorporate the chance of financial reward and loss, we show that striatal activation reflects positively signed prediction errors for both. Furthermore, we show functional segregation within the striatum, with more anterior regions showing relative selectivity for rewards and more posterior regions for losses. These findings mirror the anteroposterior valence-specific gradient reported in rodents and endorse the role of the striatum in aversive motivational learning about financial losses, illustrating functional and anatomical consistencies with primary aversive outcomes such as pain.

Original languageEnglish (US)
Pages (from-to)4826-4831
Number of pages6
JournalJournal of Neuroscience
Volume27
Issue number18
DOIs
StatePublished - May 2 2007

Fingerprint

Reward
Corpus Striatum
Cues
Rodentia
Decision Making
Learning
Pain
Brain

Keywords

  • Basal ganglia
  • Classical conditioning
  • Decision making
  • Neuroeconomics
  • Opponent process
  • Reinforcement learning

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Seymour, B., Daw, N., Dayan, P., Singer, T., & Dolan, R. (2007). Differential encoding of losses and gains in the human striatum. Journal of Neuroscience, 27(18), 4826-4831. https://doi.org/10.1523/JNEUROSCI.0400-07.2007

Differential encoding of losses and gains in the human striatum. / Seymour, Ben; Daw, Nathaniel; Dayan, Peter; Singer, Tania; Dolan, Ray.

In: Journal of Neuroscience, Vol. 27, No. 18, 02.05.2007, p. 4826-4831.

Research output: Contribution to journalArticle

Seymour, B, Daw, N, Dayan, P, Singer, T & Dolan, R 2007, 'Differential encoding of losses and gains in the human striatum', Journal of Neuroscience, vol. 27, no. 18, pp. 4826-4831. https://doi.org/10.1523/JNEUROSCI.0400-07.2007
Seymour, Ben ; Daw, Nathaniel ; Dayan, Peter ; Singer, Tania ; Dolan, Ray. / Differential encoding of losses and gains in the human striatum. In: Journal of Neuroscience. 2007 ; Vol. 27, No. 18. pp. 4826-4831.
@article{833b7d39bafb40c3b7bb962ac1fde0fb,
title = "Differential encoding of losses and gains in the human striatum",
abstract = "Studies on human monetary prediction and decision making emphasize the role of the striatum in encoding prediction errors for financial reward. However, less is known about how the brain encodes financial loss. Using Pavlovian conditioning of visual cues to outcomes that simultaneously incorporate the chance of financial reward and loss, we show that striatal activation reflects positively signed prediction errors for both. Furthermore, we show functional segregation within the striatum, with more anterior regions showing relative selectivity for rewards and more posterior regions for losses. These findings mirror the anteroposterior valence-specific gradient reported in rodents and endorse the role of the striatum in aversive motivational learning about financial losses, illustrating functional and anatomical consistencies with primary aversive outcomes such as pain.",
keywords = "Basal ganglia, Classical conditioning, Decision making, Neuroeconomics, Opponent process, Reinforcement learning",
author = "Ben Seymour and Nathaniel Daw and Peter Dayan and Tania Singer and Ray Dolan",
year = "2007",
month = "5",
day = "2",
doi = "10.1523/JNEUROSCI.0400-07.2007",
language = "English (US)",
volume = "27",
pages = "4826--4831",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "18",

}

TY - JOUR

T1 - Differential encoding of losses and gains in the human striatum

AU - Seymour, Ben

AU - Daw, Nathaniel

AU - Dayan, Peter

AU - Singer, Tania

AU - Dolan, Ray

PY - 2007/5/2

Y1 - 2007/5/2

N2 - Studies on human monetary prediction and decision making emphasize the role of the striatum in encoding prediction errors for financial reward. However, less is known about how the brain encodes financial loss. Using Pavlovian conditioning of visual cues to outcomes that simultaneously incorporate the chance of financial reward and loss, we show that striatal activation reflects positively signed prediction errors for both. Furthermore, we show functional segregation within the striatum, with more anterior regions showing relative selectivity for rewards and more posterior regions for losses. These findings mirror the anteroposterior valence-specific gradient reported in rodents and endorse the role of the striatum in aversive motivational learning about financial losses, illustrating functional and anatomical consistencies with primary aversive outcomes such as pain.

AB - Studies on human monetary prediction and decision making emphasize the role of the striatum in encoding prediction errors for financial reward. However, less is known about how the brain encodes financial loss. Using Pavlovian conditioning of visual cues to outcomes that simultaneously incorporate the chance of financial reward and loss, we show that striatal activation reflects positively signed prediction errors for both. Furthermore, we show functional segregation within the striatum, with more anterior regions showing relative selectivity for rewards and more posterior regions for losses. These findings mirror the anteroposterior valence-specific gradient reported in rodents and endorse the role of the striatum in aversive motivational learning about financial losses, illustrating functional and anatomical consistencies with primary aversive outcomes such as pain.

KW - Basal ganglia

KW - Classical conditioning

KW - Decision making

KW - Neuroeconomics

KW - Opponent process

KW - Reinforcement learning

UR - http://www.scopus.com/inward/record.url?scp=34247869023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247869023&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.0400-07.2007

DO - 10.1523/JNEUROSCI.0400-07.2007

M3 - Article

C2 - 17475790

AN - SCOPUS:34247869023

VL - 27

SP - 4826

EP - 4831

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 18

ER -