Differential effects on somatic and reflex development by chronic clomipramine treatment

Sandra Lopes De Souza, Maria Inês Nogueira, Tereza Cristina Bomfim De Jesus Deiró, Francisco MacHado Manhaes De Castro, Cristiano Mendes Da Silva, Matilde Cesiana Da Silva, Luciene Oliveira De Lira, Efrain C. Azmitia, Raul Manhaes De Castro

Research output: Contribution to journalArticle

Abstract

The developmental effect of altered 5-HT and NE levels is a subject that requires more attention, especially when considering the increased demand for antidepressive dual reuptake inhibitors. Serotonin and norepinephrine are bioamines that differentially influence the nervous tissue growth. This study investigated the somatic maturation and the ontogeny of reflexes in neonate rats treated from the 1st to the 21st postnatal day (PND) with clomipramine (20 mg/kg sc, daily), a potent monoamine reuptake inhibitor. Indicators of both general body growth (body weight, axis of the head and body lengths) and physical maturation (ear unfolding, auditory conduit opening, eruption of the lower incisors and eye opening) were appraised. Ontogeny of motor and sensory reflexes (righting, free-fall righting - acceleration, negative geotaxis, cliff avoidance, auditory startle response and vibrissa placing) was also observed. The results demonstrated that chronic neonatal treatment with clomipramine alters the somatic growth. However, it did not interfere with the onset time of many physical features and reflexes. These results provide insights into the consequences of dual transmitter during early development.

Original languageEnglish (US)
Pages (from-to)375-379
Number of pages5
JournalPhysiology and Behavior
Volume82
Issue number2-3
DOIs
StatePublished - Sep 15 2004

Fingerprint

Clomipramine
Reflex
Serotonin
Startle Reflex
Growth
Righting Reflex
Vibrissae
Nerve Tissue
Incisor
Ear
Norepinephrine
Therapeutics
Head
Body Weight

Keywords

  • Body growth
  • Clomipramine
  • Neonatal rat
  • Noradrenaline
  • Reflex ontogeny
  • Serotonin

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Physiology (medical)

Cite this

Lopes De Souza, S., Nogueira, M. I., De Jesus Deiró, T. C. B., De Castro, F. M. M., Da Silva, C. M., Da Silva, M. C., ... De Castro, R. M. (2004). Differential effects on somatic and reflex development by chronic clomipramine treatment. Physiology and Behavior, 82(2-3), 375-379. https://doi.org/10.1016/j.physbeh.2004.04.007

Differential effects on somatic and reflex development by chronic clomipramine treatment. / Lopes De Souza, Sandra; Nogueira, Maria Inês; De Jesus Deiró, Tereza Cristina Bomfim; De Castro, Francisco MacHado Manhaes; Da Silva, Cristiano Mendes; Da Silva, Matilde Cesiana; De Lira, Luciene Oliveira; Azmitia, Efrain C.; De Castro, Raul Manhaes.

In: Physiology and Behavior, Vol. 82, No. 2-3, 15.09.2004, p. 375-379.

Research output: Contribution to journalArticle

Lopes De Souza, S, Nogueira, MI, De Jesus Deiró, TCB, De Castro, FMM, Da Silva, CM, Da Silva, MC, De Lira, LO, Azmitia, EC & De Castro, RM 2004, 'Differential effects on somatic and reflex development by chronic clomipramine treatment', Physiology and Behavior, vol. 82, no. 2-3, pp. 375-379. https://doi.org/10.1016/j.physbeh.2004.04.007
Lopes De Souza S, Nogueira MI, De Jesus Deiró TCB, De Castro FMM, Da Silva CM, Da Silva MC et al. Differential effects on somatic and reflex development by chronic clomipramine treatment. Physiology and Behavior. 2004 Sep 15;82(2-3):375-379. https://doi.org/10.1016/j.physbeh.2004.04.007
Lopes De Souza, Sandra ; Nogueira, Maria Inês ; De Jesus Deiró, Tereza Cristina Bomfim ; De Castro, Francisco MacHado Manhaes ; Da Silva, Cristiano Mendes ; Da Silva, Matilde Cesiana ; De Lira, Luciene Oliveira ; Azmitia, Efrain C. ; De Castro, Raul Manhaes. / Differential effects on somatic and reflex development by chronic clomipramine treatment. In: Physiology and Behavior. 2004 ; Vol. 82, No. 2-3. pp. 375-379.
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