Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus

Mazen A. Kheirbek, Liam J. Drew, Nesha S. Burghardt, Daniel O. Costantini, Lindsay Tannenholz, Susanne E. Ahmari, Hongkui Zeng, Andre Fenton, René Henl

Research output: Contribution to journalArticle

Abstract

The dentate gyrus (DG), in addition to its role in learning and memory, is increasingly implicated in the pathophysiology of anxiety disorders. Here, we show that, dependent on their position along the dorsoventral axis of the hippocampus, DG granule cells (GCs) control specific features of anxiety and contextual learning. Using optogenetic techniques to either elevate or decrease GC activity, we demonstrate that GCs in the dorsal DG control exploratory drive and encoding, not retrieval, of contextual fear memories. In contrast, elevating the activity of GCs in the ventral DG has no effect on contextual learning but powerfully suppresses innate anxiety. These results suggest that strategies aimed at modulating the excitability of the ventral DG may be beneficial for the treatment of anxiety disorders.

Original languageEnglish (US)
Pages (from-to)955-968
Number of pages14
JournalNeuron
Volume77
Issue number5
DOIs
StatePublished - 2013

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Dentate Gyrus
Anxiety
Learning
Anxiety Disorders
Optogenetics
Fear
Hippocampus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kheirbek, M. A., Drew, L. J., Burghardt, N. S., Costantini, D. O., Tannenholz, L., Ahmari, S. E., ... Henl, R. (2013). Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron, 77(5), 955-968. https://doi.org/10.1016/j.neuron.2012.12.038

Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. / Kheirbek, Mazen A.; Drew, Liam J.; Burghardt, Nesha S.; Costantini, Daniel O.; Tannenholz, Lindsay; Ahmari, Susanne E.; Zeng, Hongkui; Fenton, Andre; Henl, René.

In: Neuron, Vol. 77, No. 5, 2013, p. 955-968.

Research output: Contribution to journalArticle

Kheirbek, MA, Drew, LJ, Burghardt, NS, Costantini, DO, Tannenholz, L, Ahmari, SE, Zeng, H, Fenton, A & Henl, R 2013, 'Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus', Neuron, vol. 77, no. 5, pp. 955-968. https://doi.org/10.1016/j.neuron.2012.12.038
Kheirbek MA, Drew LJ, Burghardt NS, Costantini DO, Tannenholz L, Ahmari SE et al. Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron. 2013;77(5):955-968. https://doi.org/10.1016/j.neuron.2012.12.038
Kheirbek, Mazen A. ; Drew, Liam J. ; Burghardt, Nesha S. ; Costantini, Daniel O. ; Tannenholz, Lindsay ; Ahmari, Susanne E. ; Zeng, Hongkui ; Fenton, Andre ; Henl, René. / Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. In: Neuron. 2013 ; Vol. 77, No. 5. pp. 955-968.
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