Diabetes-enhanced inflammation and apoptosis - Impact on periodontal pathology

D. T. Graves, R. Liu, M. Alikhani, H. Al-Mashat, P. C. Trackman

Research output: Contribution to journalArticle

Abstract

Diabetes, particularly type 2 diabetes, is a looming health issue with many ramifications. Because diabetes alters the cellular microenvironment in many different types of tissues, it causes myriad untoward effects, collectively referred to as 'diabetic complications'. Two cellular processes affected by diabetes are inflammation and apoptosis. This review discusses how diabetes-enhanced inflammation and apoptosis may affect the oral environment. In particular, dysregulation of tumor necrosis factor and the formation of advanced glycation products, both of which occur at higher levels in diabetic humans and animal models, potentiate inflammatory responses and induce apoptosis of matrix-producing cells. The enhanced loss of fibroblasts and osteoblasts through apoptosis in diabetics could contribute to limited repair of injured tissue, particularly when combined with other known deficits in diabetic wound-healing. These findings may shed light on diabetes-enhanced risk of periodontal diseases.

Original languageEnglish (US)
Pages (from-to)15-21
Number of pages7
JournalJournal of Dental Research
Volume85
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Apoptosis
Pathology
Inflammation
Cellular Microenvironment
Periodontal Diseases
Diabetes Complications
Osteoblasts
Wound Healing
Type 2 Diabetes Mellitus
Animal Models
Tumor Necrosis Factor-alpha
Fibroblasts
Health

Keywords

  • Bacteria
  • Bone
  • Cell death
  • Connective tissue
  • Cytokine
  • Diabetes
  • Gingiva
  • Hyperglycemia
  • Infection
  • Inflammatory
  • Oral
  • Periodontitis

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Diabetes-enhanced inflammation and apoptosis - Impact on periodontal pathology. / Graves, D. T.; Liu, R.; Alikhani, M.; Al-Mashat, H.; Trackman, P. C.

In: Journal of Dental Research, Vol. 85, No. 1, 01.2006, p. 15-21.

Research output: Contribution to journalArticle

Graves, DT, Liu, R, Alikhani, M, Al-Mashat, H & Trackman, PC 2006, 'Diabetes-enhanced inflammation and apoptosis - Impact on periodontal pathology', Journal of Dental Research, vol. 85, no. 1, pp. 15-21. https://doi.org/10.1177/154405910608500103
Graves, D. T. ; Liu, R. ; Alikhani, M. ; Al-Mashat, H. ; Trackman, P. C. / Diabetes-enhanced inflammation and apoptosis - Impact on periodontal pathology. In: Journal of Dental Research. 2006 ; Vol. 85, No. 1. pp. 15-21.
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