Developmental plasticity of auditory cortical inhibitory synapses

Dan Sanes, Vibhakar C. Kotak

Research output: Contribution to journalArticle

Abstract

Functional inhibitory synapses form in auditory cortex well before the onset of normal hearing. However, their properties change dramatically during normal development, and many of these maturational events are delayed by hearing loss. Here, we review recent findings on the developmental plasticity of inhibitory synapse strength, kinetics, and GABAA receptor localization in auditory cortex. Although hearing loss generally leads to a reduction of inhibitory strength, this depends on the type of presynaptic interneuron. Furthermore, plasticity of inhibitory synapses also depends on the postsynaptic target. Hearing loss leads reduced GABAA receptor localization to the membrane of excitatory, but not inhibitory neurons. A reduction in normal activity in development can also affect the use-dependent plasticity of inhibitory synapses. Even moderate hearing loss can disrupt inhibitory short- and long-term synaptic plasticity. Thus, the cortex did not compensate for the loss of inhibition in the brainstem, but rather exacerbated the response to hearing loss by further reducing inhibitory drive. Together, these results demonstrate that inhibitory synapses are exceptionally dynamic during development, and deafness-induced perturbation of inhibitory properties may have a profound impact on auditory processing.

Original languageEnglish (US)
Pages (from-to)140-148
Number of pages9
JournalHearing Research
Volume279
Issue number1-2
DOIs
StatePublished - Sep 2011

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Hearing Loss
Synapses
Auditory Cortex
GABA-A Receptors
Neuronal Plasticity
Deafness
Interneurons
Hearing
Brain Stem
Neurons
Membranes

ASJC Scopus subject areas

  • Sensory Systems

Cite this

Developmental plasticity of auditory cortical inhibitory synapses. / Sanes, Dan; Kotak, Vibhakar C.

In: Hearing Research, Vol. 279, No. 1-2, 09.2011, p. 140-148.

Research output: Contribution to journalArticle

Sanes, Dan ; Kotak, Vibhakar C. / Developmental plasticity of auditory cortical inhibitory synapses. In: Hearing Research. 2011 ; Vol. 279, No. 1-2. pp. 140-148.
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