Developmental hearing loss eliminates long-term potentiation in the auditory cortex

Vibhakar C. Kotak, Andrew D. Breithaupt, Dan Sanes

Research output: Contribution to journalArticle

Abstract

Severe hearing loss during early development is associated with deficits in speech and language acquisition. Although functional studies have shown a deafness-induced alteration of synaptic strength, it is not known whether long-term synaptic plasticity depends on auditory experience. In this study, sensorineural hearing loss (SNHL) was induced surgically in developing gerbils at postnatal day 10, and excitatory synaptic plasticity was examined subsequently in a brain slice preparation that preserves the thalamorecipient auditory cortex. Extracellular stimuli were applied at layer 6 (L6), whereas evoked excitatory synaptic potentials (EPSPs) were recorded from L5 neurons by using a whole-cell current clamp configuration. In control neurons, the conditioning stimulation of L6 significantly altered EPSP amplitude for at least 1 h. Approximately half of neurons displayed long-term potentiation (LTP), whereas the other half displayed long-term depression (LTD). In contrast, SNHL neurons displayed only LTD after the conditioning stimulation of L6. Finally, the vast majority of neurons recorded from control preheating animals (postnatal days 9-11) displayed LTD after L6 stimulation. Thus, normal auditory experience may be essential for the maturation of synaptic plasticity mechanisms.

Original languageEnglish (US)
Pages (from-to)3550-3555
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number9
DOIs
StatePublished - Feb 27 2007

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Auditory Cortex
Long-Term Potentiation
Hearing Loss
Neuronal Plasticity
Neurons
Sensorineural Hearing Loss
Excitatory Postsynaptic Potentials
Depression
Synaptic Potentials
Gerbillinae
Deafness
Language
Brain

Keywords

  • Deafness
  • Long-term depression

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Developmental hearing loss eliminates long-term potentiation in the auditory cortex. / Kotak, Vibhakar C.; Breithaupt, Andrew D.; Sanes, Dan.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 9, 27.02.2007, p. 3550-3555.

Research output: Contribution to journalArticle

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