Developmental expression of Pitx2c in Xenopus trigeminal and profundal placodes

Yeon Ho Jeong, Byung Keon Park, Jean-Pierre Saint-Jeannet, Young Hoon Lee

Research output: Contribution to journalArticle

Abstract

Cranial placodes are thickenings of the embryonic head ectoderm that contribute to the paired sense organs and to the cephalic peripheral nervous system. Here we report the spatiotemporal expression pattern of transcription factor Pitx2c during Xenopus laevis cranial placode formation, focusing more specifically on key stages of trigeminal and profundal placode development. We also compare its expression to five genes that have been associated with development of these sensory placodes, namely Foxi1c, Islet1, NeuroD, Pax3, and Six1.We show that while initially expressed in both the trigeminal and profundal placodes, Pitx2c is later restricted to the prospective profundal ganglion, where it is co-expressed with Islet1, NeuroD and Pax3. This combination of factors defines a molecular signature for the characterization of the profundal versus trigeminal ganglia in Xenopus.

Original languageEnglish (US)
Pages (from-to)701-704
Number of pages4
JournalInternational Journal of Developmental Biology
Volume58
Issue number9
DOIs
StatePublished - 2014

Fingerprint

Xenopus
Head
Sense Organs
Trigeminal Ganglion
Ectoderm
Xenopus laevis
Peripheral Nervous System
Ganglia
Transcription Factors
Genes

Keywords

  • Cranial placode
  • Pitx2c
  • Profundal
  • Trigeminal
  • Xenopus

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology

Cite this

Developmental expression of Pitx2c in Xenopus trigeminal and profundal placodes. / Jeong, Yeon Ho; Park, Byung Keon; Saint-Jeannet, Jean-Pierre; Lee, Young Hoon.

In: International Journal of Developmental Biology, Vol. 58, No. 9, 2014, p. 701-704.

Research output: Contribution to journalArticle

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