Development of visually evoked cortical activity in infant macaque monkeys studied longitudinally with fMRI

Zoe Kourtzi, Mark Augath, Nikos K. Logothetis, J. Anthony Movshon, Lynne Kiorpes

Research output: Contribution to journalArticle

Abstract

We studied the development of visual activation longitudinally in two infant monkeys aged 103-561 days using the BOLD fMRI technique under opiate anesthesia and compared the results with those obtained in three adult animals studied under identical conditions. Visual activation in primary visual cortex, V1, was strong and reliable in monkeys of the youngest and oldest ages, showing that functional imaging techniques give qualitatively similar results in infants and adults. Visual activation in extrastriate areas involved in processing motion (MT/V5) and form (V4) was not evident in the younger animals, but became more adult-like in the older animals. This delayed onset of measurable BOLD responses in extrastriate visual cortex may reflect delayed development of visual responses in these areas, although at this stage it is not possible to rule out either effects of anesthesia or of changes in cerebral vascular response mechanisms as the cause. The demonstration of visually evoked BOLD responses in young monkeys shows that the BOLD fMRI technique can usefully be employed to address functional questions of brain development.

Original languageEnglish (US)
Pages (from-to)359-366
Number of pages8
JournalMagnetic Resonance Imaging
Volume24
Issue number4
DOIs
StatePublished - May 2006

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monkeys
Macaca
Visual Cortex
Haplorhini
anesthesia
animals
Animals
cortexes
Chemical activation
Magnetic Resonance Imaging
activation
Opiate Alkaloids
Anesthesia
imaging techniques
brain
Blood Vessels
Brain
Demonstrations
Imaging techniques
causes

Keywords

  • Functional imaging
  • Macaque monkeys
  • Visual cortex
  • Visual development

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Development of visually evoked cortical activity in infant macaque monkeys studied longitudinally with fMRI. / Kourtzi, Zoe; Augath, Mark; Logothetis, Nikos K.; Movshon, J. Anthony; Kiorpes, Lynne.

In: Magnetic Resonance Imaging, Vol. 24, No. 4, 05.2006, p. 359-366.

Research output: Contribution to journalArticle

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