Development of the A1 adenosine receptors in the visual cortex of cats, dark-reared and normally reared

Research output: Contribution to journalArticle

Abstract

The ontogeny of the distribution of the binding sites for [3H]chlorohydroxyladenosine, an A1 adenosine receptor-specific ligand, was visualized autoradiographically within coronal sections of the visual cortical areas of developing cats. In adults, the A1 adenosine receptors were found in all lamina except for lamina IV, and in particularly high concentration within laminas I-III. In brains of kittens 2 months old and younger who were within the critical period for the development of visual neural function, the receptor distribution was less defined and sparser, except that in contrast to adults, it was found in relatively high concentration within lamina VI. Animals dark-reared from birth, so that the critical period was postponed, exhibited an ontogenetic pattern identical to that of the normally reared animals. These results indicate that, at least with respect to ocular dominance determination, A1 adenosine receptors are probably not involved in determining the state of plasticity that is seen during the critical period.

Original languageEnglish (US)
Pages (from-to)125-133
Number of pages9
JournalDevelopmental Brain Research
Volume22
Issue number1
DOIs
StatePublished - 1985

Fingerprint

Adenosine A1 Receptors
Visual Cortex
Cats
ocular Dominance
Sensory Receptor Cells
Binding Sites
Parturition
Ligands
Brain
Spinal Cord Dorsal Horn

Keywords

  • A adenosine receptors
  • adenosine
  • critical period
  • cyclic AMP
  • dark-rearing
  • plasticity
  • visual cortex

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Development of the A1 adenosine receptors in the visual cortex of cats, dark-reared and normally reared. / Aoki, Chiye.

In: Developmental Brain Research, Vol. 22, No. 1, 1985, p. 125-133.

Research output: Contribution to journalArticle

@article{fde5b185180e466fa85a4b2bd25cc9d1,
title = "Development of the A1 adenosine receptors in the visual cortex of cats, dark-reared and normally reared",
abstract = "The ontogeny of the distribution of the binding sites for [3H]chlorohydroxyladenosine, an A1 adenosine receptor-specific ligand, was visualized autoradiographically within coronal sections of the visual cortical areas of developing cats. In adults, the A1 adenosine receptors were found in all lamina except for lamina IV, and in particularly high concentration within laminas I-III. In brains of kittens 2 months old and younger who were within the critical period for the development of visual neural function, the receptor distribution was less defined and sparser, except that in contrast to adults, it was found in relatively high concentration within lamina VI. Animals dark-reared from birth, so that the critical period was postponed, exhibited an ontogenetic pattern identical to that of the normally reared animals. These results indicate that, at least with respect to ocular dominance determination, A1 adenosine receptors are probably not involved in determining the state of plasticity that is seen during the critical period.",
keywords = "A adenosine receptors, adenosine, critical period, cyclic AMP, dark-rearing, plasticity, visual cortex",
author = "Chiye Aoki",
year = "1985",
doi = "10.1016/0165-3806(85)90075-6",
language = "English (US)",
volume = "22",
pages = "125--133",
journal = "Developmental Brain Research",
issn = "0165-3806",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Development of the A1 adenosine receptors in the visual cortex of cats, dark-reared and normally reared

AU - Aoki, Chiye

PY - 1985

Y1 - 1985

N2 - The ontogeny of the distribution of the binding sites for [3H]chlorohydroxyladenosine, an A1 adenosine receptor-specific ligand, was visualized autoradiographically within coronal sections of the visual cortical areas of developing cats. In adults, the A1 adenosine receptors were found in all lamina except for lamina IV, and in particularly high concentration within laminas I-III. In brains of kittens 2 months old and younger who were within the critical period for the development of visual neural function, the receptor distribution was less defined and sparser, except that in contrast to adults, it was found in relatively high concentration within lamina VI. Animals dark-reared from birth, so that the critical period was postponed, exhibited an ontogenetic pattern identical to that of the normally reared animals. These results indicate that, at least with respect to ocular dominance determination, A1 adenosine receptors are probably not involved in determining the state of plasticity that is seen during the critical period.

AB - The ontogeny of the distribution of the binding sites for [3H]chlorohydroxyladenosine, an A1 adenosine receptor-specific ligand, was visualized autoradiographically within coronal sections of the visual cortical areas of developing cats. In adults, the A1 adenosine receptors were found in all lamina except for lamina IV, and in particularly high concentration within laminas I-III. In brains of kittens 2 months old and younger who were within the critical period for the development of visual neural function, the receptor distribution was less defined and sparser, except that in contrast to adults, it was found in relatively high concentration within lamina VI. Animals dark-reared from birth, so that the critical period was postponed, exhibited an ontogenetic pattern identical to that of the normally reared animals. These results indicate that, at least with respect to ocular dominance determination, A1 adenosine receptors are probably not involved in determining the state of plasticity that is seen during the critical period.

KW - A adenosine receptors

KW - adenosine

KW - critical period

KW - cyclic AMP

KW - dark-rearing

KW - plasticity

KW - visual cortex

UR - http://www.scopus.com/inward/record.url?scp=0022249884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022249884&partnerID=8YFLogxK

U2 - 10.1016/0165-3806(85)90075-6

DO - 10.1016/0165-3806(85)90075-6

M3 - Article

VL - 22

SP - 125

EP - 133

JO - Developmental Brain Research

JF - Developmental Brain Research

SN - 0165-3806

IS - 1

ER -