Development of semi-chronic microdrive system for large-scale circuit mapping in macaque mesolimbic and basal ganglia systems

Shaoyu Qiao, Kevin A. Brown, Amy L. Orsborn, Breonna Ferrentino, Bijan Pesaran

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The development of novel neurotechnologies for treating refractory neuropsychiatry disorders depends on understanding and manipulating the dynamics of neural circuits across large-scale brain networks. The mesolimbic pathway plays an essential role in reward processing and mood regulation and disorders of this pathway underlie many neuropsychiatric disorders. Here, we present the design of a customized semi-chronic microdrive array that precisely targets the anatomical structures of non-human primate (NHP) mesolimbic and basal ganglia systems. We present an integrated experimental paradigm that uses this device to map and manipulate large-scale neural circuits. The system combines electrophysiology, spatiotemporal multisite patterned intracortical microstimulation (ICMS), and diffusion tractography. We propose that this system provides a flexible platform for exploring and identifying neural signatures which can serve as novel targets for closed-loop stimulation in the clinical treatment of neuropsychiatric disorders.

Original languageEnglish (US)
Title of host publication2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages5825-5828
Number of pages4
Volume2016-October
ISBN (Electronic)9781457702204
DOIs
StatePublished - Oct 13 2016
Event38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Orlando, United States
Duration: Aug 16 2016Aug 20 2016

Other

Other38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
CountryUnited States
CityOrlando
Period8/16/168/20/16

Fingerprint

Neuropsychiatry
Diffusion Tensor Imaging
Electrophysiology
Macaca
Basal Ganglia
Mood Disorders
Reward
Primates
Equipment and Supplies
Networks (circuits)
Brain
Refractory materials
Processing

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Qiao, S., Brown, K. A., Orsborn, A. L., Ferrentino, B., & Pesaran, B. (2016). Development of semi-chronic microdrive system for large-scale circuit mapping in macaque mesolimbic and basal ganglia systems. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 (Vol. 2016-October, pp. 5825-5828). [7592052] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2016.7592052

Development of semi-chronic microdrive system for large-scale circuit mapping in macaque mesolimbic and basal ganglia systems. / Qiao, Shaoyu; Brown, Kevin A.; Orsborn, Amy L.; Ferrentino, Breonna; Pesaran, Bijan.

2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Vol. 2016-October Institute of Electrical and Electronics Engineers Inc., 2016. p. 5825-5828 7592052.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Qiao, S, Brown, KA, Orsborn, AL, Ferrentino, B & Pesaran, B 2016, Development of semi-chronic microdrive system for large-scale circuit mapping in macaque mesolimbic and basal ganglia systems. in 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. vol. 2016-October, 7592052, Institute of Electrical and Electronics Engineers Inc., pp. 5825-5828, 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, United States, 8/16/16. https://doi.org/10.1109/EMBC.2016.7592052
Qiao S, Brown KA, Orsborn AL, Ferrentino B, Pesaran B. Development of semi-chronic microdrive system for large-scale circuit mapping in macaque mesolimbic and basal ganglia systems. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Vol. 2016-October. Institute of Electrical and Electronics Engineers Inc. 2016. p. 5825-5828. 7592052 https://doi.org/10.1109/EMBC.2016.7592052
Qiao, Shaoyu ; Brown, Kevin A. ; Orsborn, Amy L. ; Ferrentino, Breonna ; Pesaran, Bijan. / Development of semi-chronic microdrive system for large-scale circuit mapping in macaque mesolimbic and basal ganglia systems. 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Vol. 2016-October Institute of Electrical and Electronics Engineers Inc., 2016. pp. 5825-5828
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