Development of glycine receptor distribution in the lateral superior olive of the gerbil

Dan Sanes, G. F. Wooten

Research output: Contribution to journalArticle

Abstract

The concentration and relative distribution of glycine receptors were determined for the gerbil lateral superior olive at several postnatal stages. Quantitative autoradiographic techniques revealed significant 3H-strychnine binding to all regions of the nucleus from 4 to 90 d. However, during the first 20 d, a nonuniform distribution of binding emerged, such that the greatest concentration of receptor was found in the high-frequency region of the nucleus. An analysis of neuron packing density showed an approximate 2-fold distribution along the same axis at all ages. This evidence is consistent with an elimination of glycine receptors in the ventral region of the lateral superior olive as maturation progresses.

Original languageEnglish (US)
Pages (from-to)3803-3811
Number of pages9
JournalJournal of Neuroscience
Volume7
Issue number11
StatePublished - 1987

Fingerprint

Glycine Receptors
Gerbillinae
Strychnine
Neurons
Superior Olivary Complex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Development of glycine receptor distribution in the lateral superior olive of the gerbil. / Sanes, Dan; Wooten, G. F.

In: Journal of Neuroscience, Vol. 7, No. 11, 1987, p. 3803-3811.

Research output: Contribution to journalArticle

@article{5b4dadee858d41bb8f6efd9cbe55b637,
title = "Development of glycine receptor distribution in the lateral superior olive of the gerbil",
abstract = "The concentration and relative distribution of glycine receptors were determined for the gerbil lateral superior olive at several postnatal stages. Quantitative autoradiographic techniques revealed significant 3H-strychnine binding to all regions of the nucleus from 4 to 90 d. However, during the first 20 d, a nonuniform distribution of binding emerged, such that the greatest concentration of receptor was found in the high-frequency region of the nucleus. An analysis of neuron packing density showed an approximate 2-fold distribution along the same axis at all ages. This evidence is consistent with an elimination of glycine receptors in the ventral region of the lateral superior olive as maturation progresses.",
author = "Dan Sanes and Wooten, {G. F.}",
year = "1987",
language = "English (US)",
volume = "7",
pages = "3803--3811",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "11",

}

TY - JOUR

T1 - Development of glycine receptor distribution in the lateral superior olive of the gerbil

AU - Sanes, Dan

AU - Wooten, G. F.

PY - 1987

Y1 - 1987

N2 - The concentration and relative distribution of glycine receptors were determined for the gerbil lateral superior olive at several postnatal stages. Quantitative autoradiographic techniques revealed significant 3H-strychnine binding to all regions of the nucleus from 4 to 90 d. However, during the first 20 d, a nonuniform distribution of binding emerged, such that the greatest concentration of receptor was found in the high-frequency region of the nucleus. An analysis of neuron packing density showed an approximate 2-fold distribution along the same axis at all ages. This evidence is consistent with an elimination of glycine receptors in the ventral region of the lateral superior olive as maturation progresses.

AB - The concentration and relative distribution of glycine receptors were determined for the gerbil lateral superior olive at several postnatal stages. Quantitative autoradiographic techniques revealed significant 3H-strychnine binding to all regions of the nucleus from 4 to 90 d. However, during the first 20 d, a nonuniform distribution of binding emerged, such that the greatest concentration of receptor was found in the high-frequency region of the nucleus. An analysis of neuron packing density showed an approximate 2-fold distribution along the same axis at all ages. This evidence is consistent with an elimination of glycine receptors in the ventral region of the lateral superior olive as maturation progresses.

UR - http://www.scopus.com/inward/record.url?scp=0023511545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023511545&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 3803

EP - 3811

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 11

ER -