Development of a photoswitchable antagonist of NMDA receptors

Felix W.W. Hartrampf, David M. Barber, Kevin Gottschling, Philipp Leippe, Michael Hollmann, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

N-methyl–Daspartate receptors (NMDARs) are vital for neurological processes such as learning, memory, and synaptic plasticity. As such, small molecules that modulate their function are of interest in the study of numerous neurological diseases. We have synthesized a small library of photoswitches that modulate NMDAR function. The most efficient photoswitch to date is based on a known ligand of the glycine binding site and shows significant subtype selectivity.

Original languageEnglish (US)
Pages (from-to)4905-4912
Number of pages8
JournalTetrahedron
Volume73
Issue number33
DOIs
StatePublished - Jan 1 2017

    Fingerprint

Keywords

  • Antagonist
  • Azobenzene
  • Photopharmacology
  • Photoswitch
  • glutamate receptor

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Hartrampf, F. W. W., Barber, D. M., Gottschling, K., Leippe, P., Hollmann, M., & Trauner, D. (2017). Development of a photoswitchable antagonist of NMDA receptors. Tetrahedron, 73(33), 4905-4912. https://doi.org/10.1016/j.tet.2017.06.056