Development of a photoswitchable antagonist of NMDA receptors

Felix W.W. Hartrampf, David M. Barber, Kevin Gottschling, Philipp Leippe, Michael Hollmann, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

N-methyl–Daspartate receptors (NMDARs) are vital for neurological processes such as learning, memory, and synaptic plasticity. As such, small molecules that modulate their function are of interest in the study of numerous neurological diseases. We have synthesized a small library of photoswitches that modulate NMDAR function. The most efficient photoswitch to date is based on a known ligand of the glycine binding site and shows significant subtype selectivity.

Original languageEnglish (US)
Pages (from-to)4905-4912
Number of pages8
JournalTetrahedron
Volume73
Issue number33
DOIs
StatePublished - 2017

Fingerprint

Neuronal Plasticity
N-Methyl-D-Aspartate Receptors
Glycine
Libraries
Binding Sites
Learning
Ligands
Plasticity
Data storage equipment
Molecules

Keywords

  • Antagonist
  • Azobenzene
  • glutamate receptor
  • Photopharmacology
  • Photoswitch

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Hartrampf, F. W. W., Barber, D. M., Gottschling, K., Leippe, P., Hollmann, M., & Trauner, D. (2017). Development of a photoswitchable antagonist of NMDA receptors. Tetrahedron, 73(33), 4905-4912. https://doi.org/10.1016/j.tet.2017.06.056

Development of a photoswitchable antagonist of NMDA receptors. / Hartrampf, Felix W.W.; Barber, David M.; Gottschling, Kevin; Leippe, Philipp; Hollmann, Michael; Trauner, Dirk.

In: Tetrahedron, Vol. 73, No. 33, 2017, p. 4905-4912.

Research output: Contribution to journalArticle

Hartrampf, FWW, Barber, DM, Gottschling, K, Leippe, P, Hollmann, M & Trauner, D 2017, 'Development of a photoswitchable antagonist of NMDA receptors', Tetrahedron, vol. 73, no. 33, pp. 4905-4912. https://doi.org/10.1016/j.tet.2017.06.056
Hartrampf FWW, Barber DM, Gottschling K, Leippe P, Hollmann M, Trauner D. Development of a photoswitchable antagonist of NMDA receptors. Tetrahedron. 2017;73(33):4905-4912. https://doi.org/10.1016/j.tet.2017.06.056
Hartrampf, Felix W.W. ; Barber, David M. ; Gottschling, Kevin ; Leippe, Philipp ; Hollmann, Michael ; Trauner, Dirk. / Development of a photoswitchable antagonist of NMDA receptors. In: Tetrahedron. 2017 ; Vol. 73, No. 33. pp. 4905-4912.
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