Determinants of elevated blood lead during pregnancy in a population surrounding a lead smelter in Kosovo, Yugoslavia

J. H. Graziano, D. Popovac, P. Factor-Litvak, Patrick Shrout, J. Kline, M. J. Murphy, Y. H. Zhao, A. Mehmeti, X. Ahmedi, B. Rajovic, Z. Zvicer, D. U. Nenezic, N. J. Lolacono, Z. Stein

Research output: Contribution to journalArticle

Abstract

We are prospectively examining the relation between environmental lead exposure and pregnancy outcome in cohorts of women exposed to a wide range of air lead concentrations. Titova Mitrovica, Yugoslavia, is the site of a large lead smelter, refinery, and battery factory. At midpregnancy, 602 women in T. Mitrovica and 900 women in Pristina, a non-lead-exposed control town, were interviewed. Blood was obtained for blood lead (PbB), hemoglobin, erythrocyte protoporphyrin, and serum ferritin measurements. Women were seen again at delivery, at which time maternal and umbilical cord blood samples were obtained. While many demographic and social characteristics were similar across the two towns, women in Pristina were more likely to report employment outside the home, cigarette smoking, and alcohol use during pregnancy. As expected, PbB levels were substantially higher in the smelter town. At midpregnancy, PbB geometric means were 17.1 μg/dL in T. Mitrovica and 5.1 μg/dL in Pristina; 86% of the pregnant women in T. Mitrovica, compared to 3.4% of those in Pristina, had PbB levels > 10 μg/dL. Within T. Mitrovica, distance between the home and the smelter was the most important predictor of PbB at mid-pregnancy and delivery. Husband's employment in the lead industry was associated with a significant increase in maternal PbB levels independent of place of residence. Higher maternal serum ferritin concentrations were associated with lower PbB levels, suggesting that dietary iron inhibits lead absorption. Overall, the placenta was a poor barrier to lead; the relationship between maternal PbB and umbilical cord PbB was linear across a wide range of PbB levels.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalEnvironmental Health Perspectives
Volume89
StatePublished - 1990

Fingerprint

Kosovo
Yugoslavia
pregnancy
Blood
blood
Pregnancy
Mothers
Population
Ferritins
serum
Dietary Iron
social characteristics
Umbilical Cord
Environmental Exposure
hemoglobin
Pregnancy Outcome
smoking
Serum
Fetal Blood
Spouses

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Graziano, J. H., Popovac, D., Factor-Litvak, P., Shrout, P., Kline, J., Murphy, M. J., ... Stein, Z. (1990). Determinants of elevated blood lead during pregnancy in a population surrounding a lead smelter in Kosovo, Yugoslavia. Environmental Health Perspectives, 89, 95-100.

Determinants of elevated blood lead during pregnancy in a population surrounding a lead smelter in Kosovo, Yugoslavia. / Graziano, J. H.; Popovac, D.; Factor-Litvak, P.; Shrout, Patrick; Kline, J.; Murphy, M. J.; Zhao, Y. H.; Mehmeti, A.; Ahmedi, X.; Rajovic, B.; Zvicer, Z.; Nenezic, D. U.; Lolacono, N. J.; Stein, Z.

In: Environmental Health Perspectives, Vol. 89, 1990, p. 95-100.

Research output: Contribution to journalArticle

Graziano, JH, Popovac, D, Factor-Litvak, P, Shrout, P, Kline, J, Murphy, MJ, Zhao, YH, Mehmeti, A, Ahmedi, X, Rajovic, B, Zvicer, Z, Nenezic, DU, Lolacono, NJ & Stein, Z 1990, 'Determinants of elevated blood lead during pregnancy in a population surrounding a lead smelter in Kosovo, Yugoslavia', Environmental Health Perspectives, vol. 89, pp. 95-100.
Graziano, J. H. ; Popovac, D. ; Factor-Litvak, P. ; Shrout, Patrick ; Kline, J. ; Murphy, M. J. ; Zhao, Y. H. ; Mehmeti, A. ; Ahmedi, X. ; Rajovic, B. ; Zvicer, Z. ; Nenezic, D. U. ; Lolacono, N. J. ; Stein, Z. / Determinants of elevated blood lead during pregnancy in a population surrounding a lead smelter in Kosovo, Yugoslavia. In: Environmental Health Perspectives. 1990 ; Vol. 89. pp. 95-100.
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AU - Graziano, J. H.

AU - Popovac, D.

AU - Factor-Litvak, P.

AU - Shrout, Patrick

AU - Kline, J.

AU - Murphy, M. J.

AU - Zhao, Y. H.

AU - Mehmeti, A.

AU - Ahmedi, X.

AU - Rajovic, B.

AU - Zvicer, Z.

AU - Nenezic, D. U.

AU - Lolacono, N. J.

AU - Stein, Z.

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N2 - We are prospectively examining the relation between environmental lead exposure and pregnancy outcome in cohorts of women exposed to a wide range of air lead concentrations. Titova Mitrovica, Yugoslavia, is the site of a large lead smelter, refinery, and battery factory. At midpregnancy, 602 women in T. Mitrovica and 900 women in Pristina, a non-lead-exposed control town, were interviewed. Blood was obtained for blood lead (PbB), hemoglobin, erythrocyte protoporphyrin, and serum ferritin measurements. Women were seen again at delivery, at which time maternal and umbilical cord blood samples were obtained. While many demographic and social characteristics were similar across the two towns, women in Pristina were more likely to report employment outside the home, cigarette smoking, and alcohol use during pregnancy. As expected, PbB levels were substantially higher in the smelter town. At midpregnancy, PbB geometric means were 17.1 μg/dL in T. Mitrovica and 5.1 μg/dL in Pristina; 86% of the pregnant women in T. Mitrovica, compared to 3.4% of those in Pristina, had PbB levels > 10 μg/dL. Within T. Mitrovica, distance between the home and the smelter was the most important predictor of PbB at mid-pregnancy and delivery. Husband's employment in the lead industry was associated with a significant increase in maternal PbB levels independent of place of residence. Higher maternal serum ferritin concentrations were associated with lower PbB levels, suggesting that dietary iron inhibits lead absorption. Overall, the placenta was a poor barrier to lead; the relationship between maternal PbB and umbilical cord PbB was linear across a wide range of PbB levels.

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