Designed 3D DNA crystals

Nadrian Seeman, Ruojie Sha, Jens Birktoft, Jianping Zheng, Wenyan Liu, Tong Wang, Chengde Mao

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The simplest practical route to producing precisely designed 3D macroscopic objects is to form a crystalline arrangement by self-assembly, because such a periodic array has only conceptually simple requirements: a motif that has a robust 3D structure, dominant affinity interactions between parts of the motif when it self-associates, and predictable structures for these affinity interactions. Fulfilling these three criteria to produce a 3D periodic system is not easy, but should readily be achieved with well-structured branched DNA motifs tailed by sticky ends (Zheng et al., Nature 461:74-77, 2009). Herein, a brief introduction to designed 3D DNA crystals from tensegrity triangle is presented.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages3-10
Number of pages8
Volume1500
DOIs
StatePublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1500
ISSN (Print)10643745

Fingerprint

Nucleotide Motifs
DNA

Keywords

  • DNA crystal
  • Self-assembly

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Seeman, N., Sha, R., Birktoft, J., Zheng, J., Liu, W., Wang, T., & Mao, C. (2017). Designed 3D DNA crystals. In Methods in Molecular Biology (Vol. 1500, pp. 3-10). (Methods in Molecular Biology; Vol. 1500). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-6454-3_1

Designed 3D DNA crystals. / Seeman, Nadrian; Sha, Ruojie; Birktoft, Jens; Zheng, Jianping; Liu, Wenyan; Wang, Tong; Mao, Chengde.

Methods in Molecular Biology. Vol. 1500 Humana Press Inc., 2017. p. 3-10 (Methods in Molecular Biology; Vol. 1500).

Research output: Chapter in Book/Report/Conference proceedingChapter

Seeman, N, Sha, R, Birktoft, J, Zheng, J, Liu, W, Wang, T & Mao, C 2017, Designed 3D DNA crystals. in Methods in Molecular Biology. vol. 1500, Methods in Molecular Biology, vol. 1500, Humana Press Inc., pp. 3-10. https://doi.org/10.1007/978-1-4939-6454-3_1
Seeman N, Sha R, Birktoft J, Zheng J, Liu W, Wang T et al. Designed 3D DNA crystals. In Methods in Molecular Biology. Vol. 1500. Humana Press Inc. 2017. p. 3-10. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-6454-3_1
Seeman, Nadrian ; Sha, Ruojie ; Birktoft, Jens ; Zheng, Jianping ; Liu, Wenyan ; Wang, Tong ; Mao, Chengde. / Designed 3D DNA crystals. Methods in Molecular Biology. Vol. 1500 Humana Press Inc., 2017. pp. 3-10 (Methods in Molecular Biology).
@inbook{bcf1700735804377b42f8c91c96d2387,
title = "Designed 3D DNA crystals",
abstract = "The simplest practical route to producing precisely designed 3D macroscopic objects is to form a crystalline arrangement by self-assembly, because such a periodic array has only conceptually simple requirements: a motif that has a robust 3D structure, dominant affinity interactions between parts of the motif when it self-associates, and predictable structures for these affinity interactions. Fulfilling these three criteria to produce a 3D periodic system is not easy, but should readily be achieved with well-structured branched DNA motifs tailed by sticky ends (Zheng et al., Nature 461:74-77, 2009). Herein, a brief introduction to designed 3D DNA crystals from tensegrity triangle is presented.",
keywords = "DNA crystal, Self-assembly",
author = "Nadrian Seeman and Ruojie Sha and Jens Birktoft and Jianping Zheng and Wenyan Liu and Tong Wang and Chengde Mao",
year = "2017",
doi = "10.1007/978-1-4939-6454-3_1",
language = "English (US)",
volume = "1500",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "3--10",
booktitle = "Methods in Molecular Biology",

}

TY - CHAP

T1 - Designed 3D DNA crystals

AU - Seeman, Nadrian

AU - Sha, Ruojie

AU - Birktoft, Jens

AU - Zheng, Jianping

AU - Liu, Wenyan

AU - Wang, Tong

AU - Mao, Chengde

PY - 2017

Y1 - 2017

N2 - The simplest practical route to producing precisely designed 3D macroscopic objects is to form a crystalline arrangement by self-assembly, because such a periodic array has only conceptually simple requirements: a motif that has a robust 3D structure, dominant affinity interactions between parts of the motif when it self-associates, and predictable structures for these affinity interactions. Fulfilling these three criteria to produce a 3D periodic system is not easy, but should readily be achieved with well-structured branched DNA motifs tailed by sticky ends (Zheng et al., Nature 461:74-77, 2009). Herein, a brief introduction to designed 3D DNA crystals from tensegrity triangle is presented.

AB - The simplest practical route to producing precisely designed 3D macroscopic objects is to form a crystalline arrangement by self-assembly, because such a periodic array has only conceptually simple requirements: a motif that has a robust 3D structure, dominant affinity interactions between parts of the motif when it self-associates, and predictable structures for these affinity interactions. Fulfilling these three criteria to produce a 3D periodic system is not easy, but should readily be achieved with well-structured branched DNA motifs tailed by sticky ends (Zheng et al., Nature 461:74-77, 2009). Herein, a brief introduction to designed 3D DNA crystals from tensegrity triangle is presented.

KW - DNA crystal

KW - Self-assembly

UR - http://www.scopus.com/inward/record.url?scp=84994525130&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994525130&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-6454-3_1

DO - 10.1007/978-1-4939-6454-3_1

M3 - Chapter

VL - 1500

T3 - Methods in Molecular Biology

SP - 3

EP - 10

BT - Methods in Molecular Biology

PB - Humana Press Inc.

ER -