Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices

Andrew B. Mahon, Paramjit Arora

Research output: Contribution to journalArticle

Abstract

Appropriately-placed hydrogen bond surrogates have been demonstrated to efficiently nucleate helical conformations. Herein we describe an efficient method for the synthesis of thioether-based hydrogen bond surrogate (teHBS) helices. A teHBS helix is shown to adopt a stable conformation and target its cognate protein receptor with high affinity.

Original languageEnglish (US)
Pages (from-to)1416-1418
Number of pages3
JournalChemical Communications
Volume48
Issue number10
DOIs
StatePublished - Feb 1 2012

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Sulfides
Hydrogen bonds
Proteins
Conformations

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices. / Mahon, Andrew B.; Arora, Paramjit.

In: Chemical Communications, Vol. 48, No. 10, 01.02.2012, p. 1416-1418.

Research output: Contribution to journalArticle

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