Design of two-phase prevalence surveys of rare disorders

Patrick Shrout, S. C. Newman

Research output: Contribution to journalArticle

Abstract

Two-phase medical surveys, in which a large sample is assessed with an inexpensive screening instrument and a subsample is selected for a more thorough diagnostic evaluation, appear to have great merit in the epidemiolgoic study of certain rare disorders. We present the optimal design of two-phase surveys when resources are fixed and when 100% of those screened positive in the first phase must be included in the second-phase evaluation. We go on to examine the relative efficiency of this two-phase design compared to a single-phase design in which all resources are used in a survey that employs the diagnostic evaluation. Given information on the accuracy of the screen and the prevalence of the disorder, the utility of the two-phase design depends on the relative cost of the screening to the diagnostic assessments.

Original languageEnglish (US)
Pages (from-to)549-555
Number of pages7
JournalBiometrics
Volume45
Issue number2
StatePublished - 1989

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Disorder
Diagnostics
Screening
Evaluation
screening
Resources
Relative Efficiency
Costs and Cost Analysis
Design
Surveys and Questionnaires
Costs
sampling
Optimal design

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics
  • Statistics and Probability
  • Public Health, Environmental and Occupational Health

Cite this

Design of two-phase prevalence surveys of rare disorders. / Shrout, Patrick; Newman, S. C.

In: Biometrics, Vol. 45, No. 2, 1989, p. 549-555.

Research output: Contribution to journalArticle

Shrout, P & Newman, SC 1989, 'Design of two-phase prevalence surveys of rare disorders', Biometrics, vol. 45, no. 2, pp. 549-555.
Shrout, Patrick ; Newman, S. C. / Design of two-phase prevalence surveys of rare disorders. In: Biometrics. 1989 ; Vol. 45, No. 2. pp. 549-555.
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