Design of a protein surface antagonist based on α-helix mimicry: Inhibition of gp41 assembly and viral fusion

Justin T. Ernst, Olaf Kutzki, Asim K. Debnath, Shibo Jiang, Hong Lu, Andrew D. Hamilton

Research output: Contribution to journalArticle

Abstract

Low micromolar inhibition of HIV-1 fusion into host cells has been achieved by using a small molecule antagonist for the disruption of the gp41 core that was designed by mimicry of the α-helical 4-3 hydrophobic repeat regions (see schematic representation).

Original languageEnglish (US)
Pages (from-to)278-281
Number of pages4
JournalAngewandte Chemie - International Edition
Volume41
Issue number2
DOIs
StatePublished - Jan 18 2002

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Keywords

  • Drug design
  • HIV
  • Proteins
  • Proteomimetics

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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