Design of a protein surface antagonist based on α-helix mimicry

Inhibition of gp41 assembly and viral fusion

Justin T. Ernst, Olaf Kutzki, Asim K. Debnath, Shibo Jiang, Hong Lu, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

Low micromolar inhibition of HIV-1 fusion into host cells has been achieved by using a small molecule antagonist for the disruption of the gp41 core that was designed by mimicry of the α-helical 4-3 hydrophobic repeat regions (see schematic representation).

Original languageEnglish (US)
Pages (from-to)278-281
Number of pages4
JournalAngewandte Chemie - International Edition
Volume41
Issue number2
DOIs
StatePublished - Jan 18 2002

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Schematic diagrams
Membrane Proteins
Fusion reactions
Molecules

Keywords

  • Drug design
  • HIV
  • Proteins
  • Proteomimetics

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Design of a protein surface antagonist based on α-helix mimicry : Inhibition of gp41 assembly and viral fusion. / Ernst, Justin T.; Kutzki, Olaf; Debnath, Asim K.; Jiang, Shibo; Lu, Hong; Hamilton, Andrew.

In: Angewandte Chemie - International Edition, Vol. 41, No. 2, 18.01.2002, p. 278-281.

Research output: Contribution to journalArticle

Ernst, Justin T. ; Kutzki, Olaf ; Debnath, Asim K. ; Jiang, Shibo ; Lu, Hong ; Hamilton, Andrew. / Design of a protein surface antagonist based on α-helix mimicry : Inhibition of gp41 assembly and viral fusion. In: Angewandte Chemie - International Edition. 2002 ; Vol. 41, No. 2. pp. 278-281.
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