Design and self-assembly of two-dimensional DNA crystals

Erik Winfree, Furong Liu, Lisa A. Wenzler, Nadrian Seeman

Research output: Contribution to journalArticle

Abstract

Molecular self-assembly presents a 'bottom-up' approach to the fabrication of objects specified with nanometre precision. DNA molecular structures and intermolecular interactions are particularly amenable to the design and synthesis of complex molecular objects. We report the design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules. Intermolecular Interactions between the structural units are programmed by the design of 'sticky ends' that associate according to Watson-Crick complementarity, enabling us to create specific periodic patterns on the nanometre scale. The patterned crystals have been visualized by atomic force microscopy.

Original languageEnglish (US)
Pages (from-to)539-544
Number of pages6
JournalNature
Volume394
Issue number6693
DOIs
StatePublished - Aug 6 1998

Fingerprint

DNA
Atomic Force Microscopy
Molecular Structure
Observation

ASJC Scopus subject areas

  • General

Cite this

Design and self-assembly of two-dimensional DNA crystals. / Winfree, Erik; Liu, Furong; Wenzler, Lisa A.; Seeman, Nadrian.

In: Nature, Vol. 394, No. 6693, 06.08.1998, p. 539-544.

Research output: Contribution to journalArticle

Winfree, E, Liu, F, Wenzler, LA & Seeman, N 1998, 'Design and self-assembly of two-dimensional DNA crystals', Nature, vol. 394, no. 6693, pp. 539-544. https://doi.org/10.1038/28998
Winfree, Erik ; Liu, Furong ; Wenzler, Lisa A. ; Seeman, Nadrian. / Design and self-assembly of two-dimensional DNA crystals. In: Nature. 1998 ; Vol. 394, No. 6693. pp. 539-544.
@article{3c592efe2e4747b7b9edd9a572878473,
title = "Design and self-assembly of two-dimensional DNA crystals",
abstract = "Molecular self-assembly presents a 'bottom-up' approach to the fabrication of objects specified with nanometre precision. DNA molecular structures and intermolecular interactions are particularly amenable to the design and synthesis of complex molecular objects. We report the design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules. Intermolecular Interactions between the structural units are programmed by the design of 'sticky ends' that associate according to Watson-Crick complementarity, enabling us to create specific periodic patterns on the nanometre scale. The patterned crystals have been visualized by atomic force microscopy.",
author = "Erik Winfree and Furong Liu and Wenzler, {Lisa A.} and Nadrian Seeman",
year = "1998",
month = "8",
day = "6",
doi = "10.1038/28998",
language = "English (US)",
volume = "394",
pages = "539--544",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Publishing Group",
number = "6693",

}

TY - JOUR

T1 - Design and self-assembly of two-dimensional DNA crystals

AU - Winfree, Erik

AU - Liu, Furong

AU - Wenzler, Lisa A.

AU - Seeman, Nadrian

PY - 1998/8/6

Y1 - 1998/8/6

N2 - Molecular self-assembly presents a 'bottom-up' approach to the fabrication of objects specified with nanometre precision. DNA molecular structures and intermolecular interactions are particularly amenable to the design and synthesis of complex molecular objects. We report the design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules. Intermolecular Interactions between the structural units are programmed by the design of 'sticky ends' that associate according to Watson-Crick complementarity, enabling us to create specific periodic patterns on the nanometre scale. The patterned crystals have been visualized by atomic force microscopy.

AB - Molecular self-assembly presents a 'bottom-up' approach to the fabrication of objects specified with nanometre precision. DNA molecular structures and intermolecular interactions are particularly amenable to the design and synthesis of complex molecular objects. We report the design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules. Intermolecular Interactions between the structural units are programmed by the design of 'sticky ends' that associate according to Watson-Crick complementarity, enabling us to create specific periodic patterns on the nanometre scale. The patterned crystals have been visualized by atomic force microscopy.

UR - http://www.scopus.com/inward/record.url?scp=0032490948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032490948&partnerID=8YFLogxK

U2 - 10.1038/28998

DO - 10.1038/28998

M3 - Article

VL - 394

SP - 539

EP - 544

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 6693

ER -