Dental enamel: genes define biomechanics.

Rick J. Rauth, Karen S. Potter, Amanda Y.W. Ngan, Deema M. Saad, Rana Mehr, Vivian Q. Luong, Verna L. Schuetter, Vetea G. Miklus, Pei Pei Chang, Michael L. Paine, Rodrigo S. Lacruz, Malcolm L. Snead, Shane N. White

Research output: Contribution to journalReview article

Abstract

Regulated gene expression assembles an extracellular proteinaceous matrix to control biomineralization and the resultant biomechanical function of tooth enamel. The importance of the dominant enamel matrix protein, amelogenin (Amel); a minor transiently expressed protein, dentin sialoprotein (Dsp); an electrogenic sodium bicarbonate cotransporter (NBCe1); the timely removal of the proteinaceous matrix by a serine protease, Kallikrein-4 (Klk4); and the late-stage expression of Amelotin (Amtn) on enamel biomechanical function were demonstrated and measured using mouse models.

Original languageEnglish (US)
Pages (from-to)863-868
Number of pages6
JournalJournal of the California Dental Association
Volume37
Issue number12
StatePublished - Dec 2009

    Fingerprint

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Rauth, R. J., Potter, K. S., Ngan, A. Y. W., Saad, D. M., Mehr, R., Luong, V. Q., Schuetter, V. L., Miklus, V. G., Chang, P. P., Paine, M. L., Lacruz, R. S., Snead, M. L., & White, S. N. (2009). Dental enamel: genes define biomechanics. Journal of the California Dental Association, 37(12), 863-868.