Dental enamel: genes define biomechanics.

Rick J. Rauth, Karen S. Potter, Amanda Y W Ngan, Deema M. Saad, Rana Mehr, Vivian Q. Luong, Verna L. Schuetter, Vetea G. Miklus, PeiPei Chang, Michael L. Paine, Rodrigo Lacruz, Malcolm L. Snead, Shane N. White

Research output: Contribution to journalArticle

Abstract

Regulated gene expression assembles an extracellular proteinaceous matrix to control biomineralization and the resultant biomechanical function of tooth enamel. The importance of the dominant enamel matrix protein, amelogenin (Amel); a minor transiently expressed protein, dentin sialoprotein (Dsp); an electrogenic sodium bicarbonate cotransporter (NBCe1); the timely removal of the proteinaceous matrix by a serine protease, Kallikrein-4 (Klk4); and the late-stage expression of Amelotin (Amtn) on enamel biomechanical function were demonstrated and measured using mouse models.

Original languageEnglish (US)
Pages (from-to)863-868
Number of pages6
JournalJournal of the California Dental Association.
Volume37
Issue number12
StatePublished - Dec 2009

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Dental Enamel
Biomechanical Phenomena
Sodium-Bicarbonate Symporters
Amelogenin
Serine Proteases
Genes
Extracellular Matrix
Tooth
Gene Expression
Proteins
enamel matrix proteins
kallikrein 4
dentin sialophosphoprotein

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Rauth, R. J., Potter, K. S., Ngan, A. Y. W., Saad, D. M., Mehr, R., Luong, V. Q., ... White, S. N. (2009). Dental enamel: genes define biomechanics. Journal of the California Dental Association., 37(12), 863-868.

Dental enamel : genes define biomechanics. / Rauth, Rick J.; Potter, Karen S.; Ngan, Amanda Y W; Saad, Deema M.; Mehr, Rana; Luong, Vivian Q.; Schuetter, Verna L.; Miklus, Vetea G.; Chang, PeiPei; Paine, Michael L.; Lacruz, Rodrigo; Snead, Malcolm L.; White, Shane N.

In: Journal of the California Dental Association., Vol. 37, No. 12, 12.2009, p. 863-868.

Research output: Contribution to journalArticle

Rauth, RJ, Potter, KS, Ngan, AYW, Saad, DM, Mehr, R, Luong, VQ, Schuetter, VL, Miklus, VG, Chang, P, Paine, ML, Lacruz, R, Snead, ML & White, SN 2009, 'Dental enamel: genes define biomechanics.', Journal of the California Dental Association., vol. 37, no. 12, pp. 863-868.
Rauth RJ, Potter KS, Ngan AYW, Saad DM, Mehr R, Luong VQ et al. Dental enamel: genes define biomechanics. Journal of the California Dental Association. 2009 Dec;37(12):863-868.
Rauth, Rick J. ; Potter, Karen S. ; Ngan, Amanda Y W ; Saad, Deema M. ; Mehr, Rana ; Luong, Vivian Q. ; Schuetter, Verna L. ; Miklus, Vetea G. ; Chang, PeiPei ; Paine, Michael L. ; Lacruz, Rodrigo ; Snead, Malcolm L. ; White, Shane N. / Dental enamel : genes define biomechanics. In: Journal of the California Dental Association. 2009 ; Vol. 37, No. 12. pp. 863-868.
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