Dendrimers as drug carriers: Dynamics of PEGylated and methotrexate-loaded dendrimers in aqueous solution

Sanja Natali, Jovan Mijovic

Research output: Contribution to journalArticle

Abstract

An investigation of the dynamics of aqueous solutions of PEG, PEGylated dendrimers, methotrexate, and PEGylated and drug (methotrexate)-loaded dendrimers was carried out with broadband dielectric relaxation spectroscopy (DRS). Two dielectric dispersions were observed in all systems, and the explanation of their molecular origin was offered. The lower frequency process, characterized by an activation energy of 52.2 kJ/mol, was attributed to motions in ice. The higher frequency process is of the Cole Cole type and is assigned to bound water around PEG and methotrexate molecules. The effect of the average number of attached PEG chains and the average number of encapsulated methotrexate molecules was probed. Our results indicate that the dynamics are independent of these numbers but are a strong function of the composition of the complex. Spectral characteristics and temperature dependence of all relaxation processes are described.

Original languageEnglish (US)
Pages (from-to)3011-3017
Number of pages7
JournalMacromolecules
Volume43
Issue number6
DOIs
StatePublished - 2010

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Dendrimers
Drug Carriers
Methotrexate
Polyethylene glycols
Molecules
Dielectric relaxation
Relaxation processes
Ice
Permittivity
Activation energy
Spectroscopy
Chemical analysis
Water
Pharmaceutical Preparations
Temperature

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Dendrimers as drug carriers : Dynamics of PEGylated and methotrexate-loaded dendrimers in aqueous solution. / Natali, Sanja; Mijovic, Jovan.

In: Macromolecules, Vol. 43, No. 6, 2010, p. 3011-3017.

Research output: Contribution to journalArticle

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