Denaturation and accelerated proteolysis of sizeable heme proteins by synthetic metalloporphyrins

Steven Fletcher, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

A synthetic, copper porphyrin unwinds the α-helical domains of the heme proteins hemoglobin, myoglobin and cytochrome c, thereby catalysing trypsin-mediated proteolysis.

Original languageEnglish (US)
Pages (from-to)623-627
Number of pages5
JournalNew Journal of Chemistry
Volume31
Issue number5
DOIs
StatePublished - 2007

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Metalloporphyrins
Proteolysis
Hemeproteins
Denaturation
Myoglobin
Hemoglobin
Porphyrins
Cytochromes c
Trypsin
Copper
Hemoglobins
Proteins

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Denaturation and accelerated proteolysis of sizeable heme proteins by synthetic metalloporphyrins. / Fletcher, Steven; Hamilton, Andrew.

In: New Journal of Chemistry, Vol. 31, No. 5, 2007, p. 623-627.

Research output: Contribution to journalArticle

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