Deconstructing Immune Microenvironments of Lymphoid Tissues for Reverse Engineering

Ini-Isabee Gunn, Rasha Nasser, Anna Garcia-Sabaté, Jiranuwat Sapudom, Chao Ma, Weiqiang Chen, Jeremy Teo

Research output: Contribution to journalReview article

Abstract

The immune microenvironment presents a diverse panel of cues that impacts immune cell migration, organization, differentiation, and the immune response. Uniquely, both the liquid and solid phases of every specific immune niche within the body play an important role in defining cellular functions in immunity at that particular location. The in vivo immune microenvironment consists of biomechanical and biochemical signals including their gradients, surface topography, dimensionality, modes of ligand presentation, and cell–cell interactions, and the ability to recreate these immune biointerfaces in vitro can provide valuable insights into the immune system. This manuscript reviews the critical roles played by different immune cells and surveys the current progress of model systems for reverse engineering of immune microenvironments with a focus on lymphoid tissues.

Original languageEnglish (US)
Article number1801126
JournalAdvanced healthcare materials
DOIs
StateAccepted/In press - Jan 1 2018

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Aptitude
Reverse engineering
Immune system
Lymphoid Tissue
Surface topography
Tissue Engineering
Cell Movement
Cues
Immune System
Immunity
Ligands
Tissue
Liquids
Surveys and Questionnaires
In Vitro Techniques

Keywords

  • biomaterials
  • immune microenvironments
  • mechanobiology
  • microfluidics

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

Deconstructing Immune Microenvironments of Lymphoid Tissues for Reverse Engineering. / Gunn, Ini-Isabee; Nasser, Rasha; Garcia-Sabaté, Anna; Sapudom, Jiranuwat; Ma, Chao; Chen, Weiqiang; Teo, Jeremy.

In: Advanced healthcare materials, 01.01.2018.

Research output: Contribution to journalReview article

Gunn, Ini-Isabee ; Nasser, Rasha ; Garcia-Sabaté, Anna ; Sapudom, Jiranuwat ; Ma, Chao ; Chen, Weiqiang ; Teo, Jeremy. / Deconstructing Immune Microenvironments of Lymphoid Tissues for Reverse Engineering. In: Advanced healthcare materials. 2018.
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