'De-evolution' of Drosophila toward a more generic mode of axis patterning

Jeremy Lynch, Claude Desplan

Research output: Contribution to journalArticle

Abstract

The genetics of the establishment of the primary axes of the early embryo have been worked out in great detail Drosophila. However, evidence has accumulated that Drosophila employs a mode of patterning that is not shared with most insects. In particular, the use of the morphogenic gradient of the Bicoid homeoprotein appears to be a novel addition to the fly developmental toolkit. To better understand the ancestral mode of patterning that is probably more widely used by insects, several groups have used Evo-Devo approaches as well as sophisticated genetic manipulations of Drosophila to achieve some form of 'de-evolution' of this derived insect. Genetic manipulations of the beetle Tribolium and the wasp Nasonia have validated most of these results.

Original languageEnglish (US)
Pages (from-to)497-503
Number of pages7
JournalInternational Journal of Developmental Biology
Volume47
Issue number7-8
StatePublished - 2003

Fingerprint

Drosophila
Insects
Tribolium
Homeodomain Proteins
Wasps
Beetles
Diptera
Embryonic Structures

Keywords

  • AP patterning
  • Evolution of Development

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

'De-evolution' of Drosophila toward a more generic mode of axis patterning. / Lynch, Jeremy; Desplan, Claude.

In: International Journal of Developmental Biology, Vol. 47, No. 7-8, 2003, p. 497-503.

Research output: Contribution to journalArticle

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