Damage to the lateral and central, but not other, amygdaloid nuclei prevents the acquisition of auditory fear conditioning

K. Nader, P. Majidishad, P. Amorapanth, Joseph Ledoux

Research output: Contribution to journalArticle

Abstract

It is well established that the amygdala plays an essential role in Pavlovian fear conditioning, with the lateral nucleus serving as the interface with sensory systems that transmit the conditioned stimulus and the central nucleus as the link with motor regions that control conditioned fear responses. The lateral nucleus connects with the central nucleus directly and by way of several other amygdala regions, including the basal, accessory basal, and medial nuclei. To determine which of these regions is necessary, and thus whether conditioning requires the direct or one of the indirect intra-amygdala pathways, we made lesions in rats of the lateral, central, basal, accessory basal, and medial nuclei, as well as combined lesions of the basal and accessory basal nuclei and of the entire amygdala. Animals subsequently underwent fear conditioning trials in which an auditory conditioned stimulus was paired with a footshock unconditioned stimulus. Animals that received lesions of the lateral or central nucleus, or of the entire amygdala, were dramatically impaired, whereas the other lesions had little effect. These findings show that only the lateral and central nuclei are necessary for the acquisition of conditioned fear response to an auditory conditioned stimulus.

Original languageEnglish (US)
Pages (from-to)156-163
Number of pages8
JournalLearning and Memory
Volume8
Issue number3
DOIs
StatePublished - 2001

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Amygdala
Fear
Intralaminar Thalamic Nuclei
Basolateral Nuclear Complex
Conditioning (Psychology)

ASJC Scopus subject areas

  • Neuroscience(all)

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Damage to the lateral and central, but not other, amygdaloid nuclei prevents the acquisition of auditory fear conditioning. / Nader, K.; Majidishad, P.; Amorapanth, P.; Ledoux, Joseph.

In: Learning and Memory, Vol. 8, No. 3, 2001, p. 156-163.

Research output: Contribution to journalArticle

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