Cytotoxic T cells directed against HLA-DR antigens and their surface proteins.

S. J. Burakoff, C. Clayberger, M. Hemler, A. M. Krensky, Carol Reiss, E. Robbins, F. Sanchez-Madrid, T. A. Springer, J. L. Strominger, C. F. Ware

Research output: Contribution to journalArticle

Abstract

The authors review their recent research involving the generation of cytotoxic T lymphocytes (CTL) directed against HLA-DR antigens. A mouse anti-human xenogeneic system first suggested that HLA-DR antigens could be recognized by CTL. Human allogeneic CTL specific for HLA-DR6 were generated and found to be OKT4+. The fact that these CTL were OKT4+ while anti HLA-A,B CTL were OKT8+ suggested that these T cell surface antigens may be involved in MHC antigen recognition; ie, they may be part of the T cell receptor. These OKT4+, HLA-DR specific CTL were further used to generate monoclonal antibodies (1) which block cytolysis and define novel antigens involved in the CTL-target interaction and (2) which define an antigenic complex on alloantigen activated T cells.

Original languageEnglish (US)
Pages (from-to)116-119
Number of pages4
JournalDiagnostic Immunology
Volume1
Issue number3
StatePublished - 1983

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T-cells
Cytotoxic T-Lymphocytes
HLA-DR Antigens
Membrane Proteins
T-Lymphocytes
HLA-DR6 Antigen
Antigens
HLA-A Antigens
HLA-B Antigens
Isoantigens
Surface Antigens
T-Cell Antigen Receptor
Monoclonal Antibodies
Research

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Burakoff, S. J., Clayberger, C., Hemler, M., Krensky, A. M., Reiss, C., Robbins, E., ... Ware, C. F. (1983). Cytotoxic T cells directed against HLA-DR antigens and their surface proteins. Diagnostic Immunology, 1(3), 116-119.

Cytotoxic T cells directed against HLA-DR antigens and their surface proteins. / Burakoff, S. J.; Clayberger, C.; Hemler, M.; Krensky, A. M.; Reiss, Carol; Robbins, E.; Sanchez-Madrid, F.; Springer, T. A.; Strominger, J. L.; Ware, C. F.

In: Diagnostic Immunology, Vol. 1, No. 3, 1983, p. 116-119.

Research output: Contribution to journalArticle

Burakoff, SJ, Clayberger, C, Hemler, M, Krensky, AM, Reiss, C, Robbins, E, Sanchez-Madrid, F, Springer, TA, Strominger, JL & Ware, CF 1983, 'Cytotoxic T cells directed against HLA-DR antigens and their surface proteins.', Diagnostic Immunology, vol. 1, no. 3, pp. 116-119.
Burakoff SJ, Clayberger C, Hemler M, Krensky AM, Reiss C, Robbins E et al. Cytotoxic T cells directed against HLA-DR antigens and their surface proteins. Diagnostic Immunology. 1983;1(3):116-119.
Burakoff, S. J. ; Clayberger, C. ; Hemler, M. ; Krensky, A. M. ; Reiss, Carol ; Robbins, E. ; Sanchez-Madrid, F. ; Springer, T. A. ; Strominger, J. L. ; Ware, C. F. / Cytotoxic T cells directed against HLA-DR antigens and their surface proteins. In: Diagnostic Immunology. 1983 ; Vol. 1, No. 3. pp. 116-119.
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