Cytokine gene variations associated with subsyndromal depressive symptoms in patients with breast cancer

Shanwell Saad, Laura B. Dunn, Theresa Koetters, Anand Dhruva, Dale J. Langford, John D. Merriman, Claudia West, Steven M. Paul, Bruce Cooper, Janine Cataldo, Deborah Hamolsky, Charles Elboim, Bradley E. Aouizerat, Christine Miaskowski

Research output: Contribution to journalArticle

Abstract

Purpose: This study explored the relationships between variations in cytokines genes and depressive symptoms in a sample of patients who were assessed prior to and for six months following breast cancer surgery. Phenotypic differences between Resilient (n = 155) and Subsyndromal (n = 180) depressive symptom classes, as well as variations in cytokine genes were evaluated. Method: Patients were recruited prior to surgery and followed for six months. Growth mixture modeling was used to identify distinct latent classes based on Center for Epidemiological Studies Depression (CES-D) Scale scores. Eighty-two single nucleotide polymorphisms and 35 haplotypes among 15 candidate cytokine genes were evaluated. Results: Patients in the Subsyndromal class were significantly younger, more likely to be married or partnered, and reported a significantly lower functional status. Variation in three cytokine genes (i.e., interferon gamma receptor 1 (IFNGR1 rs9376268), interleukin 6 (IL6 rs2069840), tumor necrosis factor alpha (TNFA rs1799964)), as well as age and functional status predicted membership in the Subsyndromal versus the Resilient class. Conclusions: A variation in TNFA that was associated with Subsyndromal depressive symptoms in a sample of patients and their family caregivers was confirmed in this sample. Variations in cytokine genes may place these patients at higher risk for the development of Subsyndromal levels of depressive symptoms.

Original languageEnglish (US)
Pages (from-to)397-404
Number of pages8
JournalEuropean Journal of Oncology Nursing
Volume18
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Depression
Breast Neoplasms
Cytokines
Genes
Interleukin-6
Haplotypes
Caregivers
Single Nucleotide Polymorphism
Epidemiologic Studies
Tumor Necrosis Factor-alpha
Growth

Keywords

  • Breast cancer
  • Cytokines
  • Depression
  • Depressive symptoms
  • Genetics
  • Interferon gamma
  • Interleukin 6
  • Subsyndromal depression
  • Tumor necrosis factor alpha

ASJC Scopus subject areas

  • Oncology(nursing)

Cite this

Cytokine gene variations associated with subsyndromal depressive symptoms in patients with breast cancer. / Saad, Shanwell; Dunn, Laura B.; Koetters, Theresa; Dhruva, Anand; Langford, Dale J.; Merriman, John D.; West, Claudia; Paul, Steven M.; Cooper, Bruce; Cataldo, Janine; Hamolsky, Deborah; Elboim, Charles; Aouizerat, Bradley E.; Miaskowski, Christine.

In: European Journal of Oncology Nursing, Vol. 18, No. 4, 2014, p. 397-404.

Research output: Contribution to journalArticle

Saad, S, Dunn, LB, Koetters, T, Dhruva, A, Langford, DJ, Merriman, JD, West, C, Paul, SM, Cooper, B, Cataldo, J, Hamolsky, D, Elboim, C, Aouizerat, BE & Miaskowski, C 2014, 'Cytokine gene variations associated with subsyndromal depressive symptoms in patients with breast cancer', European Journal of Oncology Nursing, vol. 18, no. 4, pp. 397-404. https://doi.org/10.1016/j.ejon.2014.03.009
Saad, Shanwell ; Dunn, Laura B. ; Koetters, Theresa ; Dhruva, Anand ; Langford, Dale J. ; Merriman, John D. ; West, Claudia ; Paul, Steven M. ; Cooper, Bruce ; Cataldo, Janine ; Hamolsky, Deborah ; Elboim, Charles ; Aouizerat, Bradley E. ; Miaskowski, Christine. / Cytokine gene variations associated with subsyndromal depressive symptoms in patients with breast cancer. In: European Journal of Oncology Nursing. 2014 ; Vol. 18, No. 4. pp. 397-404.
@article{b7121e46636b457bb29090f4e3feeb83,
title = "Cytokine gene variations associated with subsyndromal depressive symptoms in patients with breast cancer",
abstract = "Purpose: This study explored the relationships between variations in cytokines genes and depressive symptoms in a sample of patients who were assessed prior to and for six months following breast cancer surgery. Phenotypic differences between Resilient (n = 155) and Subsyndromal (n = 180) depressive symptom classes, as well as variations in cytokine genes were evaluated. Method: Patients were recruited prior to surgery and followed for six months. Growth mixture modeling was used to identify distinct latent classes based on Center for Epidemiological Studies Depression (CES-D) Scale scores. Eighty-two single nucleotide polymorphisms and 35 haplotypes among 15 candidate cytokine genes were evaluated. Results: Patients in the Subsyndromal class were significantly younger, more likely to be married or partnered, and reported a significantly lower functional status. Variation in three cytokine genes (i.e., interferon gamma receptor 1 (IFNGR1 rs9376268), interleukin 6 (IL6 rs2069840), tumor necrosis factor alpha (TNFA rs1799964)), as well as age and functional status predicted membership in the Subsyndromal versus the Resilient class. Conclusions: A variation in TNFA that was associated with Subsyndromal depressive symptoms in a sample of patients and their family caregivers was confirmed in this sample. Variations in cytokine genes may place these patients at higher risk for the development of Subsyndromal levels of depressive symptoms.",
keywords = "Breast cancer, Cytokines, Depression, Depressive symptoms, Genetics, Interferon gamma, Interleukin 6, Subsyndromal depression, Tumor necrosis factor alpha",
author = "Shanwell Saad and Dunn, {Laura B.} and Theresa Koetters and Anand Dhruva and Langford, {Dale J.} and Merriman, {John D.} and Claudia West and Paul, {Steven M.} and Bruce Cooper and Janine Cataldo and Deborah Hamolsky and Charles Elboim and Aouizerat, {Bradley E.} and Christine Miaskowski",
year = "2014",
doi = "10.1016/j.ejon.2014.03.009",
language = "English (US)",
volume = "18",
pages = "397--404",
journal = "European Journal of Oncology Nursing",
issn = "1462-3889",
publisher = "Churchill Livingstone",
number = "4",

}

TY - JOUR

T1 - Cytokine gene variations associated with subsyndromal depressive symptoms in patients with breast cancer

AU - Saad, Shanwell

AU - Dunn, Laura B.

AU - Koetters, Theresa

AU - Dhruva, Anand

AU - Langford, Dale J.

AU - Merriman, John D.

AU - West, Claudia

AU - Paul, Steven M.

AU - Cooper, Bruce

AU - Cataldo, Janine

AU - Hamolsky, Deborah

AU - Elboim, Charles

AU - Aouizerat, Bradley E.

AU - Miaskowski, Christine

PY - 2014

Y1 - 2014

N2 - Purpose: This study explored the relationships between variations in cytokines genes and depressive symptoms in a sample of patients who were assessed prior to and for six months following breast cancer surgery. Phenotypic differences between Resilient (n = 155) and Subsyndromal (n = 180) depressive symptom classes, as well as variations in cytokine genes were evaluated. Method: Patients were recruited prior to surgery and followed for six months. Growth mixture modeling was used to identify distinct latent classes based on Center for Epidemiological Studies Depression (CES-D) Scale scores. Eighty-two single nucleotide polymorphisms and 35 haplotypes among 15 candidate cytokine genes were evaluated. Results: Patients in the Subsyndromal class were significantly younger, more likely to be married or partnered, and reported a significantly lower functional status. Variation in three cytokine genes (i.e., interferon gamma receptor 1 (IFNGR1 rs9376268), interleukin 6 (IL6 rs2069840), tumor necrosis factor alpha (TNFA rs1799964)), as well as age and functional status predicted membership in the Subsyndromal versus the Resilient class. Conclusions: A variation in TNFA that was associated with Subsyndromal depressive symptoms in a sample of patients and their family caregivers was confirmed in this sample. Variations in cytokine genes may place these patients at higher risk for the development of Subsyndromal levels of depressive symptoms.

AB - Purpose: This study explored the relationships between variations in cytokines genes and depressive symptoms in a sample of patients who were assessed prior to and for six months following breast cancer surgery. Phenotypic differences between Resilient (n = 155) and Subsyndromal (n = 180) depressive symptom classes, as well as variations in cytokine genes were evaluated. Method: Patients were recruited prior to surgery and followed for six months. Growth mixture modeling was used to identify distinct latent classes based on Center for Epidemiological Studies Depression (CES-D) Scale scores. Eighty-two single nucleotide polymorphisms and 35 haplotypes among 15 candidate cytokine genes were evaluated. Results: Patients in the Subsyndromal class were significantly younger, more likely to be married or partnered, and reported a significantly lower functional status. Variation in three cytokine genes (i.e., interferon gamma receptor 1 (IFNGR1 rs9376268), interleukin 6 (IL6 rs2069840), tumor necrosis factor alpha (TNFA rs1799964)), as well as age and functional status predicted membership in the Subsyndromal versus the Resilient class. Conclusions: A variation in TNFA that was associated with Subsyndromal depressive symptoms in a sample of patients and their family caregivers was confirmed in this sample. Variations in cytokine genes may place these patients at higher risk for the development of Subsyndromal levels of depressive symptoms.

KW - Breast cancer

KW - Cytokines

KW - Depression

KW - Depressive symptoms

KW - Genetics

KW - Interferon gamma

KW - Interleukin 6

KW - Subsyndromal depression

KW - Tumor necrosis factor alpha

UR - http://www.scopus.com/inward/record.url?scp=84903219344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903219344&partnerID=8YFLogxK

U2 - 10.1016/j.ejon.2014.03.009

DO - 10.1016/j.ejon.2014.03.009

M3 - Article

VL - 18

SP - 397

EP - 404

JO - European Journal of Oncology Nursing

JF - European Journal of Oncology Nursing

SN - 1462-3889

IS - 4

ER -